A BGT1 antagonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

NNC 05-2090 (hydrochloride)

Item No. 42491

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[3-(9H-carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol, monohydrochloride
CAS Number
184845-18-9
Molecular Formula
C27H30N2O2 • HCl
Formula Weight
451.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Slightly Soluble: 0.1-1 mg/mlWater: Slightly Soluble: 0.1-1 mg/ml
SMILES
OC1(C2=C(OC)C=CC=C2)CCN(CC1)CCCN3C4=C(C5=C3C=CC=C5)C=CC=C4.Cl
InChi Code
InChI=1S/C27H30N2O2.ClH/c1-31-26-14-7-4-11-23(26)27(30)15-19-28(20-16-27)17-8-18-29-24-12-5-2-9-21(24)22-10-3-6-13-25(22)29;/h2-7,9-14,30H,8,15-20H2,1H3;1H
InChi Key
WDFXPKKFSNMGOO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $109

    Add

    10 mg

    $196

    Add

    25 mg

    $436

    Add

    50 mg

    $763

    Add
    Product Description

    NNC 05-2090 is an antagonist of betaine/GABA transporter 1 (BGT1; IC50 = 5.1 µM for the human transporter).1 It also inhibits mouse GABA transporter 1 (GAT1), mouse GAT2, mouse GAT3, rat serotonin transporter (SERT), rat noradrenaline transporter (NET), and rat dopamine transporter (DAT; IC50s = 29.62, 45.29, 22.51, 5.29, 7.91, and 4.08 µM, respectively, in CHO cells expressing the mouse or rat transporters).2 Intravenous administration of NNC 05-2090 (0.01 or 0.03 mg/kg) increases the latency to paw withdrawal in a mouse model of partial sciatic nerve ligation-induced allodynia. It decreases immobility time in the forced swim test in mice when administered at a dose of 2 mg/kg. NNC 05-2090 inhibits sound-induced clonic and tonic seizures and maximal electroshock-induced seizures in mice (ED50s = 26, 19, and 73 µmol/kg, respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakada, K., Yoshikawa, M., Ide, S., et al. Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transports. Bioorg. Med. Chem. 21(17), 4938-4950 (2013).

    2. Jinzenji, A., Sogawa, C., Miyawaki, T., et al. Antiallodynic action of 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methyoxyphenyl)-4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor. J. Pharmacol. Sci. 125(2), 217-226 (2014).

    3. Dalby, N.O., Thomsen, C., Fink-Jensen, A., et al. Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC 05-2090, not acting preferentially on GAT-1. Epilepsy Res. 28(1), 51-61 (1997).