A telomerase inhibitor
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360A (iodide)

Item No. 42501

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3′-[2,6-pyridinediylbis(carbonylimino)]bis[1-methyl-quinolinium, diiodide
CAS Number
737763-37-0
Molecular Formula
C27H23N5O2 • 2I
Formula Weight
703.3
Purity
≥98%
Formulation
A solid
Peptide Sequence
Solubility(Learn about Variance in Solubility)
DMSO: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CC=CC(C(NC2=CC3=C([N+](C)=C2)C=CC=C3)=O)=N1)NC4=CC5=C([N+](C)=C4)C=CC=C5.[I-].[I-]
InChi Code
InChI=1S/C27H21N5O2.2HI/c1-31-16-20(14-18-8-3-5-12-24(18)31)28-26(33)22-10-7-11-23(30-22)27(34)29-21-15-19-9-4-6-13-25(19)32(2)17-21;;/h3-17H,1-2H3;2*1H
InChi Key
CYDYPTJPHHNFEL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $208

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    10 mg

    $395

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    25 mg

    $676

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    50 mg

    $1,001

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    Cayman Chemical
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    Product Description

    360A is an inhibitor of telomerase (IC50 = 0.3 µM).1 It decreases the viability of in T98G glioma fibroblasts, CB193 astrocytoma and U-118 MG glioma cells, and primary human astrocytes (IC50s = 4.8, 3.9, 8.4, and 17.4 µM, respectively). 360A (5 µM) induces sister chromatid fusions and telomere loss in HeLa cervical cancer cells.2 It induces cell cycle arrest at the S phase and increases γ histone H2AX (γH2AX) foci, a marker of DNA damage, in GM03657 B cell lymphocytes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pennarun, G., Granotier, C., Gauthier, L.R., et al. Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene 24(18), 2917-2928 (2005).

    2. Pennarun, G., Granotier, C., Hoffschir, F., et al. Role of ATM in the telomere response to the G-quadruplex ligand 360A. Nucleic Acids Res. 36(5), 1741-1754 (2008).