A triterpenoid saponin with diverse biological activities
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Ciwujianoside B

Item No. 42502

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-30-noroleana-12,20(29)-dien-28-oic acid, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester
CAS Number
114902-16-8
Synonyms
  • Yemuoside YM10
Molecular Formula
C58H92O25
Formula Weight
1189.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Sparingly Soluble: 1-10 mg/mlDMSO: Sparingly Soluble: 1-10 mg/mlWater: Sparingly Soluble: 1-10 mg/ml
SMILES
OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]3O)O)O)O[C@H]3OC([C@]45[C@](CC(CC5)=C)([H])C6=CC[C@@]([C@@]7([C@@](C(C)([C@H](CC7)O[C@H]8[C@@H]([C@H]([C@H](CO8)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)C)([H])CC%10)C)([H])[C@]%10(C)[C@@]6(CC4)C)=O
InChi Code
InChI=1S/C58H92O25/c1-23-11-16-58(53(73)83-51-44(71)40(67)37(64)30(79-51)22-75-48-45(72)41(68)46(29(20-59)78-48)81-49-42(69)38(65)34(61)24(2)76-49)18-17-56(7)26(27(58)19-23)9-10-32-55(6)14-13-33(54(4,5)31(55)12-15-57(32,56)8)80-52-47(36(63)28(60)21-74-52)82-50-43(70)39(66)35(62)25(3)77-50/h9,24-25,27-52,59-72H,1,10-22H2,2-8H3/t24-,25-,27-,28-,29+,30+,31-,32+,33-,34-,35-,36-,37+,38+,39+,40-,41+,42+,43+,44+,45+,46+,47+,48+,49-,50-,51-,52-,55-,56+,57+,58-/m0/s1
InChi Key
UPROOJBJZLZCGS-CHTHVDMYSA-N
Origin
Plant/Eleutherococcus senticosus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    Ciwujianoside B is a triterpenoid saponin that has been found in A. senticosus and has diverse biological activities.1,2,3 It inhibits α-glucosidase and scavenges peroxynitrite radicals in cell-free assays (IC50s = 0.74 and 34.8 µM, respectively).1 Ciwujianoside B (40 mg/kg) increases survival and reverses radiation-induced decreases in the number of peripheral blood leukocytes in irradiated mice.2 It improves memory in the novel object recognition test in mice when administered at a dose of 0.5 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kwon, R.H., Na, H., Kim, J.H., et al. Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities. Sci. Rep. 14(1), 26330 (2024).

    2. Li, Y.-R., Cao, W., Guo, J., et al. Comparative investigations on the protective effects of rhodioside, ciwujianoside-B and astragaloside IV on radiation injuries of the hematopoietic system in mice. Phytother. Res. 25(5), 644-653 (2011).

    3. Yamauchi, Y., Ge, Y.-W., Yoshimatsu, K., et al. Memory enhancement by oral administration of extract of Eleutherococcus senticosus leaves and active compounds transferred in the brain. Nutrients 11(5), 1142 (2019).