An inhibitor of the TG2-fibronectin protein-protein interaction
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TG53

Item No. 42514

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-N-[4-[[4-(dimethylamino)-6-methyl-2-pyrimidinyl]amino]phenyl]-2-methoxy-benzamide
CAS Number
946369-04-6
Molecular Formula
C21H22ClN5O2
Formula Weight
411.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CC(Cl)=CC=C1OC)NC2=CC=C(NC3=NC(C)=CC(N(C)C)=N3)C=C2
InChi Code
InChI=1S/C21H22ClN5O2/c1-13-11-19(27(2)3)26-21(23-13)25-16-8-6-15(7-9-16)24-20(28)17-12-14(22)5-10-18(17)29-4/h5-12H,1-4H3,(H,24,28)(H,23,25,26)
InChi Key
JHHHSGYKBKIUBG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $76

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    10 mg

    $129

    Add

    25 mg

    $304

    Add
    Cayman Chemical
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    Product Description

    TG53 is an inhibitor of the protein-protein interaction between transglutaminase 2 (TG2) and fibronectin (IC50 = 10 µM in a cell-free assay).1 It inhibits the adhesion of SKOV3 ovarian cancer cells to fibronectin-coated wells when used at a concentration of 25 µM. TG53 (10 µM) inhibits migration and invasion in a scratch assay using SKOV3 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yakubov, B., Chen, L., Belkin, A.M., et al. Small molecule inhibitors target the tissue transglutaminase and fibronectin interaction. PLoS One 9(2), e89285 (2014).