A peptide derivative of chromogranin A and an inhibitor of norepinephrine release
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Cardiovascular System
Vasculature
Vasodilation

Catestatin (bovine)

Item No. 42518

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-seryl-L-methionyl-L-arginyl-L-leucyl-L-seryl-L-phenylalanyl-L-arginyl-L-alanyl-L-arginylglycyl-L-tyrosylglycyl-L-phenylalanyl-L-arginylglycyl-L-prolylglycyl-L-leucyl-L-glutaminyl-L-leucine
CAS Number
142211-96-9
Synonyms
  • bCgA344-364
  • Bovine Chromogranin A344-364
Molecular Formula
C107H173N37O26S
Formula Weight
2425.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
RSMRLSFRARGYGFRGPGLQL-OH
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(N[C@@H](CO[H])C(N[C@@H](CCSC)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CO[H])C(N[C@H](C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CCC/N=C(N[H])/N)C(NCC(N[C@@H](CC1=CC=C(O[H])C=C1)C(NCC(N[C@H](C(N[C@@H](CCC/N=C(N[H])/N)C(NCC(N2CCC[C@H]2C(NCC(N[C@H](C(N[C@@H](CCC(N[H])=O)C(N[C@H](C(O)=O)CC(C)C)=O)=O)CC(C)C)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)C)=O)=O)CC4=CC=CC=C4)=O)=O)CC(C)C)=O)=O)=O)[C@H](CCC/N=C(N[H])/N)N[H]
InChi Code
InChI=1S/C107H173N37O26S/c1-57(2)45-72(95(162)137-70(35-36-81(109)148)93(160)141-77(102(169)170)47-59(5)6)130-84(151)53-127-101(168)80-30-20-43-144(80)85(152)54-128-89(156)67(27-17-40-122-105(114)115)134-97(164)75(48-61-21-11-9-12-22-61)132-83(150)52-126-90(157)74(50-63-31-33-64(147)34-32-63)131-82(149)51-125-88(155)66(26-16-39-121-104(112)113)133-86(153)60(7)129-91(158)68(28-18-41-123-106(116)117)136-98(165)76(49-62-23-13-10-14-24-62)140-100(167)79(56-146)143-96(163)73(46-58(3)4)139-92(159)69(29-19-42-124-107(118)119)135-94(161)71(37-44-171-8)138-99(166)78(55-145)142-87(154)65(108)25-15-38-120-103(110)111/h9-14,21-24,31-34,57-60,65-80,145-147H,15-20,25-30,35-56,108H2,1-8H3,(H2,109,148)(H,125,155)(H,126,157)(H,127,168)(H,128,156)(H,129,158)(H,130,151)(H,131,149)(H,132,150)(H,133,153)(H,134,164)(H,135,161)(H,136,165)(H,137,162)(H,138,166)(H,139,159)(H,140,167)(H,141,160)(H,142,154)(H,143,163)(H,169,170)(H4,110,111,120)(H4,112,113,121)(H4,114,115,122)(H4,116,117,123)(H4,118,119,124)/t60-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-/m0/s1
InChi Key
HCEYIDADOJWYIM-DIWOTYQXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $105

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    10 mg

    $189

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    25 mg

    $418

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    50 mg

    $732

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    Product Description

    Catestatin is a peptide derivative of chromogranin A and an inhibitor of norepinephrine release.1 It inhibits nicotine-induced secretion of norepinephrine and nicotine-induced sodium intake in PC12 rat adrenal medulla cells (IC50s = ~0.2 and ~0.25 µM, respectively). Catestatin decreases mean arterial blood pressure and current-induced pressor response and increases plasma levels of epinephrine and histamine in pithed rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mahata, S.K., O'Connor, D.T., Mahata, M., et al. Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist. J. Clin. Invest. 100(6), 1623-1633 (1997).

    2. Kennedy, B.P., Mahata, S.K., O'Connor, D.T., et al. Mechanism of cardiovascular actions of the chromogranin A fragment catestatin in vivo. Peptides 19(7), 1241-1248 (1998).