A siloxane-incorporated ionizable cationic lipidoid
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Si5-N14

Item No. 42520

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3’,3’’,3’’’-(((1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-tetradecylpropanamide)
CAS Number
3006860-57-4
Molecular Formula
C78H160N6O5Si2
Formula Weight
1318.3
Purity
≥95%
Formulation (Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(CCN(CCC[Si](C)(C)O[Si](C)(CCCN(CCC(NCCCCCCCCCCCCCC)=O)CCC(NCCCCCCCCCCCCCC)=O)C)CCC(NCCCCCCCCCCCCCC)=O)NCCCCCCCCCCCCCC
InChi Code
InChI=1S/C78H160N6O5Si2/c1-9-13-17-21-25-29-33-37-41-45-49-53-63-79-75(85)59-69-83(70-60-76(86)80-64-54-50-46-42-38-34-30-26-22-18-14-10-2)67-57-73-90(5,6)89-91(7,8)74-58-68-84(71-61-77(87)81-65-55-51-47-43-39-35-31-27-23-19-15-11-3)72-62-78(88)82-66-56-52-48-44-40-36-32-28-24-20-16-12-4/h9-74H2,1-8H3,(H,79,85)(H,80,86)(H,81,87)(H,82,88)
InChi Key
QJDZHMBJSTXKDI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $424

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    Cayman Chemical
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    Product Description

    Si5-N14 is a siloxane-incorporated ionizable cationic lipidoid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and single-guide RNA (sgRNA) in vitro and in vivo.1 LNPs containing Si5-N14 and encapsulating a luciferase mRNA reporter exhibit increased cellular uptake via micropinocytosis and lipid raft-mediated endocytosis pathways and endosomal escape compared with LNPs containing non-siloxane-incorporated lipids in immortalized human lung microvascular endothelial cells (iMVECs). In vivo, LNPs containing Si5-N14 and encapsulating a luciferase mRNA reporter selectively accumulate in the lungs in mice. Si5-N14 LNPs encapsulating Cas9 mRNA and GFP sgRNA reduce GFP levels in lung MVECs without increasing bronchoalveolar lavage fluid (BALF) cytokine levels in a transgenic GFP mouse model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xue, L., Zhao, G., Gong, N., et al. Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery. Nat. Nanotechnol. 20(1), 132-143 (2025).