An imidazole antifungal agent
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Lanoconazole

Item No. 42532

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αE-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile
CAS Number
101530-10-3
Synonyms
  • NND-318
  • TJN-318
Molecular Formula
C14H10ClN3S2
Formula Weight
319.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
N#C/C(N1C=CN=C1)=C2SCC(C3=C(Cl)C=CC=C3)S/2
InChi Code
InChI=1S/C14H10ClN3S2/c15-11-4-2-1-3-10(11)13-8-19-14(20-13)12(7-16)18-6-5-17-9-18/h1-6,9,13H,8H2/b14-12+
InChi Key
ZRTQSJFIDWNVJW-WYMLVPIESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $54

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    10 mg

    $92

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    25 mg

    $175

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    Product Description

    Lanoconazole is an imidazole antifungal agent.1 It is active against several strains of T. mentagrophytes and T. rubrum (mean MICs = 0.025 and 0.0054 µg/ml, respectively). Lanoconazole (10 µM) inhibits S. cerevisiae β-glucan-induced IL-8 release in primary human epidermal keratinocytes and phytohemagglutinin-induced IFN-γ and IL-2 release in primary human peripheral blood mononuclear cells (PBMCs).2 In vivo, lanoconazole (20 µl of a 3% solution) decreases ear thickness in a mouse model of irritant dermatitis induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014). Topical application of lanoconazole (0.5%) decreases T. mentagrophytes infection score intensity in a guinea pig model of tinea pedis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Niwano, Y., Kuzuhara, N., Kodama, J., et al. In vitro and in vivo antidermatophyte activities of NND-502, a novel optically active imidazole antimycotic agent. Antimicrob. Agents and Chemother. 42(4), 967-970 (1998).

    2. Uratsuji, H., Nakamura, A., Yamada, Y., et al. Anti-inflammatory activity of lanoconazole, a topical antifungal agent. Mycoses 58(4), 197-202 (2015).