A BMP signaling activator
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SJ000063181

Item No. 42546

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-chloro-4-fluorophenyl)-5-(2-methylpropyl)-3-isoxazolecarboxamide
CAS Number
945189-68-4
Synonyms
  • Ventromorphin 2
  • Vm2
Molecular Formula
C14H14ClFN2O2
Formula Weight
296.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
ClC1=CC(NC(C2=NOC(CC(C)C)=C2)=O)=CC=C1F
InChi Code
InChI=1S/C14H14ClFN2O2/c1-8(2)5-10-7-13(18-20-10)14(19)17-9-3-4-12(16)11(15)6-9/h3-4,6-8H,5H2,1-2H3,(H,17,19)
InChi Key
PBZNVOPQXYXTPC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $138

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    10 mg

    $235

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    25 mg

    $482

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    50 mg

    $757

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    Product Description

    SJ000063181 is a bone morphogenetic protein (BMP) signaling activator.1 It activates BMP4 in C33A-2D2 human cervical carcinoma clonal reporter cells (EC50 = ≤1 µM). SJ000063181 (6.25 µM) induces ventralization, as well as increases expression of the BMP target genes bmp2b and szl and the cooperatively induced BMP target genes vent and vox in zebrafish embryos. It also increases the stability of survival motor neuron protein (SMN; EC50 = 1.5 µM) in a reporter assay using the SMN2 gene, which produces an unstable truncated SMN protein.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Genthe, J.R., Min, J., Farmer, D.M., et al. Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathway. ACS Chem. Biol. 12(9), 2436-2447 (2017).

    2. Rietz, A., Li, H., Quist, K.M., et al. Discovery of a small molecule probe that post-translationally stabilizes the survival motor neuron protein for the treatment of spinal muscular atrophy. J. Med. Chem. 60(11), 4594-4610 (2017).