A peptide agonist of NPY receptors
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Nisotirostide

Item No. 42551

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-prolyl-L-lysyl-L-prolyl-L-α-glutamyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-L-α-glutamyl-6-aminohexanoyl]-L-lysyl-L-prolylglycyl-L-α-glutamyl-L-α-aspartyl-L-alanyl-L-seryl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tryptophyl-L-glutaminyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-alanyl-L-α-glutamyl-L-leucyl-L-arginyl-L-histidyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-threonyl-L-arginyl-L-glutaminyl-L-arginyl-L-tyrosinamide
CAS Number
2663844-45-7
Synonyms
  • LY3457263
Molecular Formula
C230H343N59O65
Formula Weight
4974.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
PKPEK-(6-aminohexanamide-Glu-γGlu-18-oxo-octadecanoic acid)-PEDASPEEWNRYYELRHYLNWLTRNRY-NH2
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
OC1=CC=C(C=C1)C[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H]([C@H](O)C)NC([C@H](CC(C)C)NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC4=CC=C(O)C=C4)NC([C@H](CC5=CNC=N5)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC6=CC=C(O)C=C6)NC([C@H](CC7=CC=C(O)C=C7)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CC8=CNC9=C8C=CC=C9)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H]%10N(C([C@H](CO)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CCC(O)=O)NC(CNC([C@H]%11N(C([C@H](CCCCNC(CCCCCNC([C@@H](NC(CC[C@H](NC(CCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)CCC(O)=O)=O)=O)NC([C@H](CCC(O)=O)NC([C@H]%12N(C([C@H](CCCCN)NC([C@H]%13NCCC%13)=O)=O)CCC%12)=O)=O)=O)CCC%11)=O)=O)=O)=O)=O)=O)CCC%10)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C230H343N59O65/c1-123(2)105-161(210(337)264-147(52-38-100-250-229(240)241)200(327)282-169(114-135-119-244-122-255-135)216(343)279-166(111-132-66-74-139(295)75-67-132)212(339)275-162(106-124(3)4)211(338)283-170(115-178(234)298)217(344)281-168(113-134-118-253-143-46-29-27-44-141(134)143)215(342)276-163(107-125(5)6)218(345)286-191(128(9)291)222(349)270-148(53-39-101-251-230(242)243)197(324)265-151(76-85-176(232)296)202(329)262-145(50-36-98-248-227(236)237)198(325)273-160(192(235)319)108-129-60-68-136(292)69-61-129)274-206(333)153(81-90-186(309)310)261-193(320)126(7)256-208(335)164(109-130-62-70-137(293)71-63-130)278-213(340)165(110-131-64-72-138(294)73-65-131)277-199(326)146(51-37-99-249-228(238)239)263-203(330)152(77-86-177(233)297)267-214(341)167(112-133-117-252-142-45-28-26-43-140(133)142)280-207(334)154(82-91-187(311)312)266-204(331)155(83-92-188(313)314)268-221(348)175-56-42-104-289(175)225(352)172(121-290)285-194(321)127(8)257-209(336)171(116-190(317)318)284-201(328)150(80-89-185(307)308)259-182(302)120-254-219(346)173-54-40-102-287(173)223(350)158(272-205(332)156(84-93-189(315)316)269-220(347)174-55-41-103-288(174)224(351)157(47-30-32-94-231)271-196(323)144-49-35-97-245-144)48-31-34-95-246-179(299)57-24-22-33-96-247-195(322)149(79-88-184(305)306)258-181(301)87-78-159(226(353)354)260-180(300)58-23-20-18-16-14-12-10-11-13-15-17-19-21-25-59-183(303)304/h26-29,43-46,60-75,117-119,122-128,144-175,191,245,252-253,290-295H,10-25,30-42,47-59,76-116,120-121,231H2,1-9H3,(H2,232,296)(H2,233,297)(H2,234,298)(H2,235,319)(H,244,255)(H,246,299)(H,247,322)(H,254,346)(H,256,335)(H,257,336)(H,258,301)(H,259,302)(H,260,300)(H,261,320)(H,262,329)(H,263,330)(H,264,337)(H,265,324)(H,266,331)(H,267,341)(H,268,348)(H,269,347)(H,270,349)(H,271,323)(H,272,332)(H,273,325)(H,274,333)(H,275,339)(H,276,342)(H,277,326)(H,278,340)(H,279,343)(H,280,334)(H,281,344)(H,282,327)(H,283,338)(H,284,328)(H,285,321)(H,286,345)(H,303,304)(H,305,306)(H,307,308)(H,309,310)(H,311,312)(H,313,314)(H,
InChi Key
FUJAXTAKFUGOHA-HXYPJNMFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Nisotirostide is a peptide agonist of neuropeptide Y (NPY) receptors.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nicze, M., Dec, A., Borówka, M., et al. Molecular mechanisms behind obesity and their potential exploitation in current and future therapy. Int. J. Mol. Sci. 25(15), 8202 (2024).