A partial agonist of α7 nAChRs
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DMAB-anabaseine (hydrochloride)

Item No. 42562

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(5,6-dihydro[2,3′-bipyridin]-3(4H)-ylidene)methyl]-N,N-dimethyl-benzenamine, dihydrochloride
CAS Number
154149-38-9
Molecular Formula
C19H21N3 • 2HCl
Formula Weight
364.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Sparingly Soluble: 1-10 mg/ml
SMILES
CN(C)C1=CC=C(C=C2CCCN=C2C3=CC=CN=C3)C=C1.Cl.Cl
InChi Code
InChI=1S/C19H21N3.2ClH/c1-22(2)18-9-7-15(8-10-18)13-16-5-4-12-21-19(16)17-6-3-11-20-14-17;;/h3,6-11,13-14H,4-5,12H2,1-2H3;2*1H
InChi Key
DHCNEWWWKHBASC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $464

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    10 mg

    $818

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    25 mg

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    Product Description

    DMAB-anabaseine is a partial agonist of α7 nicotinic acetylcholine receptors (nAChRs).1 It induces currents in a whole-cell patch-clamp assay using Xenopus oocytes expressing human α7 nAChRs (EC50 = 21 µM). Intracerebroventricular administration of DMAB-anabaseine (80 µg/animal) inhibits nicotine-induced prostration in rats.2 It decreases prepulse inhibition deficits in sensory inhibition-deficient DBA/2J mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zwart, R., Strotton, M., Ching, J., et al. Unique pharmacology of heteromeric α7β2 nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. Eur. J. Pharmacol. 726, 77-86 (2014).

    2. Kem, W.R., Mahnir, V.M., Papke, R.L., et al. Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J. Pharmacol. Exp. Ther. 283(3), 979-992 (1997).

    3. Stevens, K.E., Kem, W.R., Mahnir, V.M., et al. Selective α7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacol. (Berl) 136(4), 320-327 (1998).