A 5-HT2C receptor agonist
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Bexicaserin

Item No. 42569

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,2-difluoroethyl)-1,2,3,4,6,7-hexahydro-7R-methyl-pyrrolo[3,2,1-jk][1,4]benzodiazepine-8-carboxamide
CAS Number
2035818-24-5
Synonyms
  • LP352
Molecular Formula
C15H19F2N3O
Formula Weight
295.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
C[C@@H](C1)C2=C(C(NCC(F)F)=O)C=CC3=C2N1CCNC3
InChi Code
InChI=1S/C15H19F2N3O/c1-9-8-20-5-4-18-6-10-2-3-11(13(9)14(10)20)15(21)19-7-12(16)17/h2-3,9,12,18H,4-8H2,1H3,(H,19,21)/t9-/m0/s1
InChi Key
KGOOOHQKLRUVSF-VIFPVBQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $45

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    5 mg

    $180

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    Product Description

    Bexicaserin is an agonist of the serotonin (5-HT) receptor subtype 5-HT2C.1 It selectively stimulates the accumulation of inositol phosphate in HEK cells expressing the 5-HT2C receptor (EC50 = 42 nM) over those expressing the 5-HT2A or 5-HT2B receptors (EC50s = >50,000 nM for both). Bexicaserin (10 mg/kg, p.o.) reduces food intake by 81% in fasted rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ren, A., Zhu, X., Lehmann, J., et al. Diazepine agonists of the 5‑HT2C receptor with unprecedented selectivity: Discovery of bexicaserin (LP352). J. Med Chem. 68(11), 10599-10618 (2025).