A turn-on fluorescent and photoacoustic probe for lipid-associated hydroxyl radicals
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Cy-OH-LP

Item No. 42571

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-2-((E)-2-(2-chloro-3-((E)-2-(1,3,3-trimethylindolin-2-yl)vinyl)cyclohex-2-en-1-ylidene)ethylidene)-1,3,3-trimethylindoline
Synonyms
  • Cy-hydroxy-LP
Molecular Formula
C32H37ClN2
Formula Weight
485.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
CHCl3: Slightly Soluble: 0.1-1 mg/ml
SMILES
ClC1=C(/C=C/C2C(C)(C)C(C=CC=C3)=C3N2C)CCC/C1=C\C=C4C(C)(C)C5=C(C=CC=C5)N/4C
InChi Code
InChI=1S/C32H37ClN2/c1-31(2)24-14-7-9-16-26(24)34(5)28(31)20-18-22-12-11-13-23(30(22)33)19-21-29-32(3,4)25-15-8-10-17-27(25)35(29)6/h7-10,14-21,28H,11-13H2,1-6H3/b20-18+,23-19+,29-21+
InChi Key
ISHWLQNMIAHJOB-PQRQDRCGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $50

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    5 mg

    $198

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    Product Description

    Cy-OH-LP is a turn-on fluorescent and photoacoustic probe for the detection of lipid-associated hydroxyl radicals.1 In the presence of hydroxyl radicals, Cy-OH-LP is oxidized to Cy7, which displays weak fluorescent and photoacoustic signals in water-soluble environments and strong fluorescent and photoacoustic signals in lipid-rich environments due to its lipid solubility. Cy-OH-LP (1 mg/kg) has been used for photoacoustic imaging of hydroxyl radicals in atherosclerotic plaques in ApoE-/- mice fed a high-fat diet.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, F.-K., Cao, J., Zhang, T., et al. Dual-activated photoacoustic probe for reliably detecting hydroxyl radical in ischemic cardiovascular disease in mouse and human samples. ACS Sens. 9(10), 5445-5453 (2024).