An ionizable cationic lipid
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THP1 Lipid

Item No. 42585

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,6-tetrahydro-1,3-dioctyl-4,5-pyrimidinedicarboxylic acid, 4,5-diethyl ester
CAS Number
3097638-13-3
Synonyms
  • Tetrahydropyrimidine 1 Lipid
Molecular Formula
C26H48N2O4
Formula Weight
452.7
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
O=C(OCC)C1=C(C(OCC)=O)N(CCCCCCCC)CN(CCCCCCCC)C1
InChi Code
InChI=1S/C26H48N2O4/c1-5-9-11-13-15-17-19-27-21-23(25(29)31-7-3)24(26(30)32-8-4)28(22-27)20-18-16-14-12-10-6-2/h5-22H2,1-4H3
InChi Key
BOOXYBQPTLWJAA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $109

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    10 mg

    $196

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    25 mg

    $464

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    50 mg

    $818

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    Cayman Chemical
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    Product Description

    THP1 lipid is an ionizable cationic lipid (pKa = 5.451) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing THP1 lipid and encapsulating mRNA encoding luciferase induce luciferase expression in HEK293 and RAW 264.7 cells. LNPs containing THP1 lipid and 1-palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; Item No. 20067) accumulate in mouse liver after intravenous administration and have a higher transfection efficiency than LNPs containing DLin-MC3-DMA (Item No. 34364). THP1 lipid-containing LNPs encapsulating Cre mRNA induce the expression of tdTomato in the liver of Ai14 mice engineered to express tdTomato upon Cre-mediated recombination.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Isaac, I., Shaikh, A., Bhatia, M., et al. Tetrahydropyrimidine ionizable lipids for efficient mRNA delivery. ACS Nano 18(42), 29045-29058 (2024).