A vitamin B5-derived ionizable cationic lipid
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Lipid I97

Item No. 42607

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O,O'-((R)-4-((3-(2-(dimethylamino)ethoxy)-3-oxopropyl)amino)-2,2-dimethyl-4-oxobutane-1,3-diyl) bis(2-hexyldecyl) diglutarate
CAS Number
3046404-81-0
Synonyms
  • I97
Molecular Formula
C55H102N2O11
Formula Weight
967.4
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Methyl Acetate: Soluble: ≥10 mg/ml
SMILES
O=C(NCCC(OCCN(C)C)=O)[C@H](OC(CCCC(OCC(CCCCCCCC)CCCCCC)=O)=O)C(C)(COC(CCCC(OCC(CCCCCC)CCCCCCCC)=O)=O)C
InChi Code
InChI=1S/C55H102N2O11/c1-9-13-17-21-23-27-33-46(31-25-19-15-11-3)43-65-48(58)35-29-37-50(60)67-45-55(5,6)53(54(63)56-40-39-51(61)64-42-41-57(7)8)68-52(62)38-30-36-49(59)66-44-47(32-26-20-16-12-4)34-28-24-22-18-14-10-2/h46-47,53H,9-45H2,1-8H3,(H,56,63)/t46?,47?,53-/m0/s1
InChi Key
QWNGWGVVAZJBLB-ORVWFSQNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $720

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    Product Description

    Lipid I97 is a vitamin B5-derived ionizable cationic lipid (pKa = 6.23) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing lipid I97 and encapsulating luciferase mRNA selectively accumulate in the spleen and lymph nodes in mice. LNPs containing lipid I97 and encapsulating mRNA encoding hemagglutinin A induce IgG1 and IgG2 production in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoo, S., Faisal, M., Bae, S.-H., et al. Novel less toxic, lymphoid tissue-targeted lipid nanoparticles containing a vitamin B5-derived ionizable lipid for mRNA vaccine delivery. Adv. Healthc. Mater. e2403366 (2024).