A lexitropsin antibiotic
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MGB-BP-3

Item No. 42613

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-N-[1-methyl-5-[[[2-(4-morpholinyl)ethyl]amino]carbonyl]-1H-pyrrol-3-yl]-4-[[4-[(1E)-2-(3-quinolinyl)ethenyl]benzoyl]amino]-1H-pyrrole-2-carboxamide
CAS Number
1000277-08-6
Molecular Formula
C36H37N7O4
Formula Weight
631.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(C1=CC=C(/C=C/C(C=N2)=CC3=C2C=CC=C3)C=C1)NC4=CN(C)C(C(NC5=CN(C)C(C(NCCN6CCOCC6)=O)=C5)=O)=C4
InChi Code
InChI=1S/C36H37N7O4/c1-41-24-30(20-32(41)35(45)37-13-14-43-15-17-47-18-16-43)40-36(46)33-21-29(23-42(33)2)39-34(44)27-11-9-25(10-12-27)7-8-26-19-28-5-3-4-6-31(28)38-22-26/h3-12,19-24H,13-18H2,1-2H3,(H,37,45)(H,39,44)(H,40,46)/b8-7+
InChi Key
OEKXCVYZBVOWBR-BQYQJAHWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    MGB-BP-3 is a lexitropsin antibiotic.1,2 It binds to bacterial dsDNA and is active against S. aureus, S. faecalis, and M. fortuitum, as well as C. albicans (MICs = 3, 25, 50, and 50 µg/ml, respectively). In vivo, MGB-BP-3 (40 mg/kg) decreases joint inflammation severity in a mouse model of joint sepsis induced by S. aureus.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hind, C., Clifford, M., Woolley, C., et al. Insights into the spectrum of activity and mechanism of action of MGB-BP-3. ACS Infect. Dis. 8(12), 2552-2563 (2022).

    2. Anthony, N.G., Breen, D., Clarke, J., et al. Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups. J. Med. Chem. 50(24), 6116-6125 (2007).