A hapten
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2,4-Dinitrobenzenesulfonic Acid (sodium salt)

Item No. 42630

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dinitro-benzenesulfonic acid, monosodium salt
CAS Number
885-62-1
Synonyms
  • 2,4-DNBSA
  • DNBS
  • DNBSO3
Molecular Formula
C6H3N2O7S • Na
Formula Weight
270.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly Soluble: 1-10 mg/ml
SMILES
[O-]S(=O)(C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O)=O.[Na+]
InChi Code
InChI=1S/C6H4N2O7S.Na/c9-7(10)4-1-2-6(16(13,14)15)5(3-4)8(11)12;/h1-3H,(H,13,14,15);/q;+1/p-1
InChi Key
GSBYVRKLPCSLNV-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $42

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    10 g

    $47

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    25 g

    $70

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    Product Description

    2,4-Dinitrobenzenesulfonic acid is a hapten.1 It induces the proliferation of primary lymphocytes and epithelial cells isolated from guinea pigs sensitized to 2,4-dinitrochlorobenzene (2,4-DNCB) when used at concentrations of 25, 50, or 100 ppm. 2,4-Dinitrobenzenesulfonic acid (600 mg/kg) inhibits 2,4-DNCB-induced contact sensitivity in 2,4-DNCB-sensitized guinea pigs.2 It has been used to induce ulcerative colitis in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Q., and Aoyama, K. In vitro evaluation on contact sensitivity from DNCB and DNBS using lymphocyte blastogenesis response test. Sangyo Igaku 33(6), 509-518 (1991).

    2. Frey, J.R., de Weck, A.L., and Geleick, H. Studies on the induction of immunological tolerance by antigen in guinea-pigs already sensitized to dinitrochlorobenzene. Clin. Exp. Immunol. 8(1), 131-139 (1971).

    3. Kim, S., Lee, S., Lee, H., et al. A colon-targeted prodrug, 4-phenylbutyric acid-glutamic acid conjugate, ameliorates 2,4-dinitrobenzenesulfonic acid-induced colitis in rats. Pharmaceutics 12(9), 843 (2020).