A diterpene toxin
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Grayanotoxin III

Item No. 42645

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
Grayanotoxane-3β,5,6β,10,14R,16-hexol
CAS Number
4678-45-9
Synonyms
  • Andromedol
  • Deacetylandromedotoxin
  • Deacylasebotoxin I
  • GTX-III
  • NSC 323778
Molecular Formula
C20H34O6
Formula Weight
370.5
Purity
≥90%
Formulation (Request formulation change)
A 1 mg/ml solution in acetonitrile:water (1:1)
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlWater: Slightly Soluble: 0.1-1 mg/ml
SMILES
O[C@H]1[C@@]23[C@](CC[C@@]1([H])[C@](O)(C3)C)([H])[C@@](O)([C@@]4([H])[C@]([C@@H](C2)O)(C(C)([C@H](C4)O)C)O)C
InChi Code
InChI=1S/C20H34O6/c1-16(2)13(21)7-12-18(4,25)11-6-5-10-15(23)19(11,9-17(10,3)24)8-14(22)20(12,16)26/h10-15,21-26H,5-9H2,1-4H3/t10-,11+,12+,13+,14-,15-,17-,18-,19+,20+/m1/s1
InChi Key
BWMFRQKICHXLSH-FIRPSQKQSA-N
Origin
Plant/Rhododendron sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    100 µg

    $439

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    Product Description

    Grayanotoxin III (GTX-III) is a diterpene toxin that has been found in R. ponticum nectar, a component of mad honey.1 In vivo, GTX-III (0.1 and 0.25 mg/kg) induces salivation, emesis, and hind paw paralysis in mice.2 It is lethal to mice (LD50 = 0.84 mg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kurtoglu, A.B., Yavuz, R., and Evrendilek, G.A. Characterisation and fate of grayanatoxins in mad honey produced from Rhododendron ponticum nectar. Food Chem. 161, 47-52 (2014).

    2. Ohgaki, T., Uchida, S., Meguri, H., et al. Preventive action of quisqualic acid against grayanotoxin-induced suppression of locomotor activity in mice. Neuropharmacology 27(10), 1045-1053 (1988).