A diterpene toxin
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Grayanotoxin III

Item No. 42645

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
Grayanotoxane-3β,5,6β,10,14R,16-hexol
CAS Number
4678-45-9
Synonyms
  • Andromedol
  • Deacetylandromedotoxin
  • Deacylasebotoxin I
  • GTX-III
  • NSC 323778
Molecular Formula
C20H34O6
Formula Weight
370.5
Purity
≥90%
Formulation
A solution in water:acetonitrile
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlWater: Slightly Soluble: 0.1-1 mg/ml
SMILES
O[C@H]1[C@@]23[C@](CC[C@@]1([H])[C@](O)(C3)C)([H])[C@@](O)([C@@]4([H])[C@]([C@@H](C2)O)(C(C)([C@H](C4)O)C)O)C
InChi Code
InChI=1S/C20H34O6/c1-16(2)13(21)7-12-18(4,25)11-6-5-10-15(23)19(11,9-17(10,3)24)8-14(22)20(12,16)26/h10-15,21-26H,5-9H2,1-4H3/t10-,11+,12+,13+,14-,15-,17-,18-,19+,20+/m1/s1
InChi Key
BWMFRQKICHXLSH-FIRPSQKQSA-N
Origin
Plant/Rhododendron sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 µg

    $439

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Grayanotoxin III (GTX-III) is a diterpene toxin that has been found in R. ponticum nectar, a component of mad honey.1 In vivo, GTX-III (0.1 and 0.25 mg/kg) induces salivation, emesis, and hind paw paralysis in mice.2 It is lethal to mice (LD50 = 0.84 mg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kurtoglu, A.B., Yavuz, R., and Evrendilek, G.A. Characterisation and fate of grayanatoxins in mad honey produced from Rhododendron ponticum nectar. Food Chem. 161, 47-52 (2014).

    2. Ohgaki, T., Uchida, S., Meguri, H., et al. Preventive action of quisqualic acid against grayanotoxin-induced suppression of locomotor activity in mice. Neuropharmacology 27(10), 1045-1053 (1988).