A gut microbiota-derived metabolite and uremic toxin
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4-Ethylphenyl Sulfate

Item No. 42654

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-ethyl-phenol 1-(hydrogen sulfate)
CAS Number
85734-98-1
Synonyms
  • 4-EPS
  • 4-Ethylphenol Sulfate
Molecular Formula
C8H10O4S
Formula Weight
202.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS pH 7.2: Soluble: ≥10 mg/ml
SMILES
O=S(O)(OC1=CC=C(CC)C=C1)=O
InChi Code
InChI=1S/C8H10O4S/c1-2-7-3-5-8(6-4-7)12-13(9,10)11/h3-6H,2H2,1H3,(H,9,10,11)
InChi Key
DWZGLEPNCRFCEP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $78

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    100 mg

    $148

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    250 mg

    $312

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    Product Description

    4-Ethylphenyl sulfate is a gut microbiota-derived metabolite of tyrosine and a uremic toxin.1,2 It decreases the viability of HCT116 colon cancer cells when used at concentrations of 5 or 10 mM.3 4-Ethylphenyl sulfate decreases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiety-like activity.1 Plasma and liver levels of 4-ethylphenyl sulfate are increased in a rat model of chronic kidney disease induced by adenine (Item No. 18148).2 Plasma levels of 4-ethylphenyl sulfate are also increased in patients with autism spectrum disorder.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Needham, B.D., Funabashi, M., Adame, M.D., et al. A gut-derived metabolite alters brain activity and anxiety behaviour in mice. Nature 602(7898), 647-653 (2022).

    2. Hartjes, E.D., Lim, Y.J., Velenosi, T.J., et al. The impact of progressive chronic kidney disease on hepatic drug metabolism. Drug Metab. Dispos. 53(6), 100085 (2025).

    3. Jaiswal, J., Srivastav, A.K., Kushwaha, M., et al. Gut microbial metabolite 4-ethylphenylsulfate is selectively deleterious and anticancer to colon cancer cells. J. Med. Chem. 68(10), 10425-10438 (2025).

    4. Needham, B.D., Adame, M.D., Serena, G., et al. Plasma and fecal metabolite profiles in autism spectrum disorder. Biol. Psychiatry 89(5), 451-462 (2021).