An ionizable cationic lipid
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31hP

Item No. 42706

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
undecan-3-yl 4-(1-((2-(diethylamino)ethyl)(methyl)amino)-7-(heptadecan-9-yloxy)-7-oxohept-2-yn-1-yl)benzoate
Molecular Formula
C49H86N2O4
Formula Weight
767.2
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
CCN(CC)CCN(C)C(C#CCCCC(OC(CCCCCCCC)CCCCCCCC)=O)C1=CC=C(C(OC(CC)CCCCCCCC)=O)C=C1
InChi Code
InChI=1S/C49H86N2O4/c1-8-14-17-20-23-27-32-45(11-4)55-49(53)44-39-37-43(38-40-44)47(50(7)41-42-51(12-5)13-6)35-30-26-31-36-48(52)54-46(33-28-24-21-18-15-9-2)34-29-25-22-19-16-10-3/h37-40,45-47H,8-29,31-34,36,41-42H2,1-7H3
InChi Key
LGWPDVVSVBJOPF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $196

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    25 mg

    $464

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    50 mg

    $818

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    Cayman Chemical
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    Product Description

    31hP is an ionizable cationic lipid (pKa = 6.25) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and single-guide RNA (sgRNA) in vitro and in vivo.1 Intravenous administration of LNPs containing 31hP and encapsulating mRNA encoding Cas9 and sgRNA targeting transthyretin (TTR) reduce serum TTR levels in mice to a greater extent than those containing DLin-MC3-DMA (Item No. 34364). Intramuscular administration of LNPs containing 31hP and encapsulating mRNA encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein increases serum antibody titers in mice to a greater extent than those containing SM-102 (Item No. 33474).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Han, X., Alameh, M.-G., Xu, Y., et al. Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution. Nat. Biomed. Eng. 8(11), 1412-1424 (2024).