An EP2 agonist
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Evatanepag

Item No. 42727

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[3-[[[[4-(1,1-dimethylethyl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]-acetic acid
CAS Number
223488-57-1
Synonyms
  • CP 533,536
Molecular Formula
C25H28N2O5S
Formula Weight
468.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 0.1-1 mg/ml
SMILES
O=C(COC1=CC=CC(CN(S(=O)(C2=CC=CN=C2)=O)CC3=CC=C(C(C)(C)C)C=C3)=C1)O
InChi Code
InChI=1S/C25H28N2O5S/c1-25(2,3)21-11-9-19(10-12-21)16-27(33(30,31)23-8-5-13-26-15-23)17-20-6-4-7-22(14-20)32-18-24(28)29/h4-15H,16-18H2,1-3H3,(H,28,29)
InChi Key
WOHRHWDYFNWPNG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $174

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    10 mg

    $308

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    25 mg

    $578

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    Product Description

    Evatanepag is an agonist of prostaglandin E2 (PGE2) receptor subtype EP2.1 It induces cAMP accumulation in cells expressing rat EP2 (EC50 = 0.3 nM). Evatanepag (3 mg/kg) increases total bone area, mineral content, and mineral density in rat tibia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cameron, K.O., Lefker, B.A., Ke, H.Z., et al. Discovery of CP-533536: An EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. Bioorg. Med. Chem. Lett. 19(7), 2075-2078 (2009).