An antimicrobial peptide
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Polybia-MP1 (trifluoroacetate salt)

Item No. 42735

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-isoleucyl-L-α-aspartyl-L-tryptophyl-L-lysyl-L-lysyl-L-leucyl-L-leucyl-L-α-aspartyl-L-alanyl-L-alanyl-L-lysyl-L-glutaminyl-L-isoleucyl-L-leucinamide, trifluoroacetate salt
Synonyms
  • Polybia-MPI
Molecular Formula
C78H132N20O19 • XCF3COOH
Formula Weight
1654.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
IDWKKLLDAAKQIL-NH2
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
CC(C)C[C@@H](C(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H](N)[C@@H](C)CC)=O)=O)CC1=CNC2=CC=CC=C12)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C78H132N20O19.C2HF3O2/c1-13-43(9)63(83)77(116)97-59(38-62(102)103)76(115)95-57(36-47-39-85-49-24-16-15-23-48(47)49)75(114)90-51(26-18-21-31-80)69(108)89-52(27-19-22-32-81)70(109)93-55(34-41(5)6)73(112)94-56(35-42(7)8)74(113)96-58(37-61(100)101)72(111)87-45(11)66(105)86-46(12)67(106)88-50(25-17-20-30-79)68(107)91-53(28-29-60(82)99)71(110)98-64(44(10)14-2)78(117)92-54(65(84)104)33-40(3)4;3-2(4,5)1(6)7/h15-16,23-24,39-46,50-59,63-64,85H,13-14,17-22,25-38,79-81,83H2,1-12H3,(H2,82,99)(H2,84,104)(H,86,105)(H,87,111)(H,88,106)(H,89,108)(H,90,114)(H,91,107)(H,92,117)(H,93,109)(H,94,112)(H,95,115)(H,96,113)(H,97,116)(H,98,110)(H,100,101)(H,102,103);(H,6,7)/t43-,44-,45-,46-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-,64-;/m0./s1
InChi Key
LVLZKCHCKFKPQT-FLKJMJLMSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Polybia-MP1 is an antimicrobial peptide that has been found in wasp (P. paulista) venom.1 It is active against E. coli, P. aeruginosa, B. subtilis, and S. aureus (MICs = 8, 8, 4, and 15 µg/ml, respectively). Polybia-MP1 induces degranulation (EC50 = 45 µM) and lysis of isolated rat peritoneal mast cells but does not induce hemolysis of washed isolated rat erythrocytes. It also induces chemotaxis of polymorphonuclear leukocytes (PMN) in a concentration-dependent manner. Polybia-MP1 (20 µM) induces necrosis in T98G glioblastoma multiforme (GBM) cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Souza, B.M., Mendes, M.A., Santos, L.D., et al. Structural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista. Peptides 26(11), 2157-2167 (2005).

    2. da Silva, A.M., Silva-Gonçalves, L.C., Oliveira, F.A., et al. Pro-necrotic activity of cationic mastoparan peptides in human glioblastoma multiforme cells via membranolytic action. Mol. Neurobiol. 55(7), 5490-5504 (2018).