IFNAR1 (human, recombinant)

IFN α/β receptor 1 (IFNAR1), also known as type I IFN receptor 1, is a class II helical cytokine receptor involved in the antiviral response.¹ It is composed of an extracellular domain, which contains four fibronectin type III subdomains, a transmembrane domain, and an intracellular domain, which contains a tyrosine kinase 2 (TYK2) phosphorylation site, and forms a heterodimer with IFNAR2.² It is ubiquitously expressed and binds to type I IFNs, including IFN-α, IFN-β, and IFN-ω, which, upon binding, together with IFNAR2 signal through JAK1, TYK2, and various STATs.³ Knockout of Ifnar1 sensitizes fibroblasts to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vitro and has commonly been used as an immunosuppressive model to study viral infections in vivo.^4,5 SNPs in IFNAR1 are associated with increased risk of viral infections, lung cancer, multiple sclerosis, and cerebral malaria, as well as adverse reactions to vaccinations.¹ Cayman's IFNAR1 (human, recombinant) protein consists of 409 amino acids and has a calculated molecular weight of 50.1 kDa. As a result of glycosylation, the monomer migrates at approximately 70-90 kDa by SDS-PAGE under reducing conditions.

WARNING This product is not for human or veterinary use.

1. de Weerd, N.A., Vivian, J.P., Lim, S.S., et al. Structural integrity with functional plasticity: What type I IFN receptor polymorphisms reveal. J. Leukoc. Biol. 108(3), 909-924 (2020).

2. Borden, E.C., Sen, G.C., Uze, G., et al. Interferons at age 50: Past, current and future impact on biomedicine. Nat. Rev. Drug Discov. 6(12), 975-990 (2007).

3. de Weerd, N.A., and Nguyen, T. The interferons and their receptors - distribution and regulation. Immunol. Cell Biol. 90(5), 483-491 (2012).

4. Zhang, Q., Bastard, P., Liu, Z., et al. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 370(6515), eabd4570 (2020).

5. Marín-Lopez, A., Calvo-Pinilla, E., Moreno, S., et al. Modeling arboviral infection in mice lacking the interferon alpha/beta receptor. Viruses 11(1), 35 (2019).