Active • Host: E. coli • AA: 32-194 • Tag: N-terminal His • MW: 21 kDa
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FGF7 (human, recombinant)

Item No. 42756

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Fibroblast Growth Factor 7
  • HBGF-7
  • Heparin-binding Growth Factor 7
  • Keratinocyte Growth Factor
Purity
≥95% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg determined by the LAL endotoxin assay
Source
Active recombinant human N-terminal His-tagged FGF7 expressed in E. coli
Amino Acids
32-194
MW
21 kDa
Formulation (Request formulation change)
Lyophilized from sterile 50 mM Tris, pH 7.5, with 250 mM sodium chloride, 5% trehalose, 5% mannitol, and 0.01% polysorbate 80
Host
E. coli
UniProt Accession №
P21781
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    20 µg

    $149

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    100 µg

    $297

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    1 mg

    $2,600

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    Cayman Chemical
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    Product Description

    Fibroblast growth factor 7 (FGF7), also known as keratinocyte growth factor (KGF), is a member of the FGF7 subfamily.1,2 It is composed of an N-terminal signaling region, which is cleaved prior to secretion, a Cα backbone, a heparin-binding domain, and a receptor-binding domain.2,3 FGF7 is secreted by stromal fibroblasts and forms a quaternary complex with FGFR2b dimers, and to a lesser extent FGFR1b dimers, with heparan sulfate proteoglycans to induce ERK- or MAPK-induced proliferation in epithelial cells.4,3,1 It is also necessary for proper nephron and hippocampal development and post-radiation thymic regeneration in mice.4 Knockout of Fgf7 decreases cartilage erosion, osteophyte formation, bone density, and subchondral bone plate thickness in a mouse model of osteoarthritis induced by destabilization of the medial meniscus (DMM).5 Increased levels of FGF7 in cancer-associated fibroblasts are correlated with increased arterial and lymphatic metastasis, increased amount of residual tumor following surgery, and advanced cancer staging in patients with ovarian cancer.6 Cayman's FGF7 (human, recombinant) protein can be used for cell-based assays. This protein consists of 162 amino acids and has a calculated molecular weight of 21 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mason, I. Initiation to end point: The multiple roles of fibroblast growth factors in neural development. Nat. Rev. Neurosci. 8(8), 583-596 (2007).

    2. Ye, S., Luo, Y., Lu, W., et al. Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs. Biochemistry 40(48), 14429-14439 (2001).

    3. Finch, P.W., Rubin, J.S., Miki, T., et al. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 245(4919), 752-755 (1989).

    4. Zinkle, A., and Mohammadi, M. Structural biology of the FGF7 subfamily. Front. Genet. 10, 102 (2019).

    5. Shin, Y., Kwak, J.-S., Kim, S.K., et al. Fibroblast growth factor 7 (FGF7) causes cartilage destruction, subchondral bone remodeling, and the premature growth plate closure in mice. Osteoarthritis Cartilage (2024).

    6. Feng, S., Ding, B., Dai, Z., et al. Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter. J. Transl. Med. 22(1), 280 (2024).