Host: HEK293 cells • AA: 25-116 • MW: 10.2 kDa
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

hCGα (human, recombinant)

Item No. 42766

Product Insert (PDF)
Technical Information
Synonyms
  • Follicle-stimulating Hormone Subunit α
  • FSHα
  • Glycoprotein Hormone α
  • Human Chorionic Gonadotropin α
  • Human Chorionic Gonadotropin Subunit α
  • LHα
  • Luteinizing Hormone Subunit α
  • Thyroid Stimulating Hormone Subunit α
  • TSHα
Purity
≥97% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/μg, determined by the LAL endotoxin assay
Source
Recombinant hCGα expressed in HEK293 cells
Amino Acids
25-116
MW
10.2 kDa
Storage Buffer
Lyophilized from sterile PBS, pH 7.4.
Host
HEK293 cells
UniProt Accession №
P01215
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 µg

    $328

    Add
    Product Description

    Human chorionic gonadotropin subunit α (hCGα) is a hormone subunit and a member of the gonadothyrotropin hormone family.1,2 It is composed of a central cysteine knot that forms disulfide bridges with hCGβ or β subunits from other hormones, including luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid stimulating hormone (TSH). Dimerization of these hormones with hCGα activates the LH receptor (LHR), FSH receptor (FSHR), or thyroid stimulating hormone receptor (TSHR).2,3 hCGα is expressed in and secreted from the anterior pituitary gland and placenta.3 hCGα has roles in promoting angiogenesis in the uterus during pregnancy, growth of fetal organs, gonad development and maturation, and production and secretion of progesterone and thyroid hormones.1,4,5,6 Cayman's hCGα (human, recombinant) protein consists of 92 amino acids and has a calculated molecular weight of 10.2 kDa. By SDS-PAGE, the apparent molecular mass of the protein is approximately 25 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cole, L.A. Biological functions of hCG and hCG-related molecules. Reprod. Biol. Endocrinol. 8, 102 (2010).

    2. Lapthorn, A.J., Harris, D.C., Littlejohn, A., et al. Crystal structure of human chorionic gonadotropin. Nature 369(6480), 455-461 (1994).

    3. Garcia-Campayo, V., Kumar, T.R., and Boime, I. Thyrotropin, follitropin, and chorionic gonadotropin expressed as a single multifunctional unit reveal remarkable permissiveness in receptor-ligand interactions. Endocrinology 143(10), 3773-3778 (2002).

    4. Eblen, A., Bao, S., Lei, Z.M., et al. The presence of functional luteinizing hormone/chorionic gonadotropin receptors in human sperm. J. Clin. Endocrinol. Metab. 86(6), 2643-2648 (2001).

    5. Simoni, M., Gromoll, J., and Nieschlag, E. The follicle-stimulating hormone receptor: Biochemistry, molecular biology, physiology, and pathophysiology. Endocr. Rev. 18(6), 739-773 (1997).

    6. Bassett, J.H., and Williams, G.R. Role of thyroid hormones in skeletal development and bone maintenance. Endocr. Rev. 37(2), 135-187 (2016).