For immunochemical detection of GATA3
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GATA3 Rabbit Monoclonal Antibody (Clone RM482)

Item No. 42776

Product Insert (PDF)
Technical Information
Synonyms
  • GATA-binding Factor 3
  • Trans-acting T cell-specific Transcription Factor GATA3
Immunogen
Peptide corresponding to human GATA3
Clone Designation
RM482
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) GATA3
Species Reactivity
(+) Human(+) Mouse(+) Rat
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    GATA3 is a zinc finger protein and transcription factor with roles in cell differentiation and organogenesis.1,2 It is composed of two N-terminal transactivating domains and two C-terminal zinc finger domains.3 GATA3 is expressed in hematopoietic cells, neurons, adipose tissue, mammary glands, renal tissue, skin, hair, parathyroid glands, and skeletal muscle.1 It functions as a primary transcription factor in germ cell specification programs and regulates the redistribution of T cell populations from Th2 to Th1 T helper cells. Mutations in GATA3 are associated with the autosomal dominant disorder hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR) syndrome, also known as Barakat syndrome.3 GATA3 downregulation is associated with poor prognosis and increased mortality in patients with urothelial malignancies.2 Cayman’s GATA3 Rabbit Monoclonal Antibody (Clone RM482) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bacha, R., Pedersen, S., Ismail, R., et al. GATA3: Orchestrating cellular fate through differentiation and proliferation. Biochim. Biophys. Acta Mol. Cell Res. 1872(2), 119893 (2025).

    2. Khazaeli Najafabadi, M., Mirzaeian, E., Memar Montazerin, S., et al. Role of GATA3 in tumor diagnosis: A review. Pathol. Res. Pract. 226:153611, (2021).

    3. Huang, B., Li, S., Chai, Y., et al. A novel GATA3 frameshift mutation causes hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome. Mol. Genet. Metab. Rep. 38:101063, (2024).