For immunochemical detection of claudin-18.2
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Claudin-18.2 Rabbit Monoclonal Antibody (Clone RM510)

Item No. 42777

Product Insert (PDF)
Technical Information
Synonyms
  • Claudin-18.A2
  • Claudin 18 isoform 2
Immunogen
Peptide corresponding to residues of human claudin-18.2
Clone Designation
RM510
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC
Cross Reactivity
(+) Claudin-18.2
Species Reactivity
(+) Human(+) Mouse(+) Rat
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µL

    $411

    Add
    Cayman Chemical
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    Product Description

    Claudin 18 isoform 2 (claudin-18.2) is a member of the claudin family of tight junction proteins.1,2 CLDN18 is expressed as two isoforms, claudin-18.1 and claudin-18.2, that differ in their N-terminal domains and tissue expression.3 Both claudin-18 isoforms are composed of two cytoplasmic domains, four transmembrane domains, and two extracellular loops.1 Claudin-18.2 is predominantly expressed in gastric epithelium.3,1 It forms tight junctions between epithelial cells and prevents paracellular hydrogen ion leakage.1,2 The levels of claudin-18.2 are increased in tumor tissue from patients with gastric adenocarcinoma.4 Formulations containing monoclonal antibodies targeting claudin-18.2 have been used in the treatment of gastric or gastroesophageal junction adenocarcinoma. Cayman’s Claudin-18.2 Rabbit Monoclonal Antibody (Clone RM510) can be used for immunohistochemistry (IHC) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakayama, I., Qi, C., Chen, Y., et al. Claudin 18.2 as a novel therapeutic target. Nat. Rev. Clin. Oncol. 21(5), 354-369 (2024).

    2. Tsukita, S., Tanaka, H., and Tamura, A. The claudins: From tight junctions to biological systems. Trends Biochem. Sci. 44(2), 141-152 (2019).

    3. Türeci, Ö., Koslowski, M., Helftenbein, G., et al. Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals. Gene 481(2), 83-92 (2011).

    4. Rohde, C., Yamaguchi, R., Mukhina, S., et al. Comparison of Claudin 18.2 expression in primary tumors and lymph node metastases in Japanese patients with gastric adenocarcinoma. Jpn. J. Clin. Oncol. 49(9), 870-876 (2019).