For immunochemical detection of TRPS1
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TRPS1 Rabbit Monoclonal Antibody (Clone RM518)

Item No. 42784

Technical Information
Synonyms
  • GC79
  • Trichorhinophalangeal Syndrome Type 1 Protein
Immunogen
Recombinant protein corresponding to human TRPS1
Clone Designation
RM518
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) TRPS1
Species Reactivity
(+) Human(+) Mouse(+) Rat
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Product Description

    TRPS1 is a member of the GATA-like family of zinc finger transcription factors.1 It is composed of seven zinc-finger domains, a cysteine-rich region, a GATA-like zinc-finger domain, and two Ikaros-like zinc-finger domains. TRPS1 is ubiquitously expressed and found in the nucleus where it binds GATA-binding sequences and functions as a transcriptional repressor.1,2 It is involved in organ development, cell cycle regulation and progression, and the regulation of bone and tooth mineralization.3,4,2 Deletion or loss-of-function mutations in TRPS1 are associated with Langer-Giedion syndrome, also known as trichorhinophalangeal syndrome type 1, a condition characterized by learning disabilities, craniofacial abnormalities, ectodermal dysplasia, hip malformations, and decreased stature.5 Cayman's TRPS1 Rabbit Monoclonal Antibody (Clone RM518) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, G.T.G., van den Bemd, G.-J.C.M., Jhamai, M., et al. Structure and function of GC79/TRPS1, a novel androgen-repressible apoptosis gene. Apoptosis 7(1), 13-21 (2002).

    2. Yang, L., Gong, X., Wang, J., et al. Functional mechanisms of TRPS1 in disease progression and its potential role in personalized medicine. Pathol. Res. Pract. 237, 154022 (2022).

    3. Kuzynski, M., Goss, M., Bottini, M., et al. Dual role of the Trps1 transcription factor in dentin mineralization. The Journal of Biological Chemisty (2014).

    4. Wu, L., Wang, Y., Liu, Y., et al. A central role for TRPS1 in the control of cell cycle and cancer development. Oncotarget 5(17), 7677-7690 (2014).

    5. Momeni, P., Glöckner, G., Schmidt, O., et al. Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I. Nat. Genet. 24(1), 71-74 (2000).