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SV2A Rabbit Monoclonal Antibody (Clone RM520)

Item No. 42786

Product Insert (PDF)
Technical Information
Formal Name
For immunochemical detection of SV2A
Synonyms
  • Synaptic Vesicle Glycoprotein 2A
Immunogen
A peptide corresponding to the N-terminus of human SV2A
Clone Designation
RM520
Formulation (Request formulation change)
100 μl of protein A-affinity purified antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) SV2A
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µl

    $411

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    Product Description

    Synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane glycoprotein and member of the keratan sulfate proteoglycan family.1 It is composed of N- and C-terminal cytosolic domains and 12 transmembrane domains interspersed with two ATP-binding regions, a cytoplasmic loop, and an extracellular loop.2 SV2A also contains multiple glycosylation and phosphorylation sites.3 It is ubiquitously expressed in the brain, with brain region-dependent expression in glutamatergic or GABAergic neurons, and localizes to the presynaptic membrane.4,5 It is also expressed in the peripheral nervous system in sympathetic synapses, slow motoneurons, and platelets, as well as in the pancreas.3 SV2A interacts with synaptotagmin-1 (Syt1), a protein involved in calcium-dependent synaptic vesicle fusion, and is involved in trafficking Syt1 during synaptic vesicle endocytosis.2 Glycosylated SV2 proteins, including SV2A, act as receptors for C. botulinum neurotoxin type A1.5,4 Biallelic loss-of-function mutations in SV2A are associated with epileptic encephalopathy, a disorder characterized by early-onset epilepsy, microcephaly, and neurodevelopmental delay.6 Cayman’s SV2A Rabbit Monoclonal Antibody (Clone RM520) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rossi, R., Arjmand, S., Bærentzen, S.L., et al. Synaptic vesicle glycoprotein 2A: Features and functions. Front. Neurosci. 16, (2022).

    2. Hogg, J.A., and Cousin, M.A. Control of synaptotagmin-1 trafficking by SV2A-mechanism and consequences for presynaptic function and dysfunction. J. Neurochem. 169(1), e16308 (2025).

    3. Stout, K.A., Dunn, A.R., Hoffman, C., et al. The synaptic vesicle glycoprotein 2: Structure, function, and disease relevance. ACS Chem. Neurosci. 10(9), 3927-3938 (2019).

    4. Gustafsson, R., Zhang, S., Masuyer, G., et al. Crystal structure of botulinum neurotoxin A2 in complex with the human protein receptor SV2C reveals plasticity in receptor binding. Toxins (Basel) 10(4), 153 (2018).

    5. Gregory, K.S., and Acharya, K.R. A comprehensive structural analysis of Clostridium botulinum neurotoxin a cell-binding domain from different subtypes. Toxins (Basel) 15(2), 92 (2023).

    6. Al-Maawali, A., Al-Murshedi, F., Al-Futaisi, A., et al. Biallelic variants in the synaptic vesicle glycoprotein 2 A are associated with epileptic encephalopathy. Eur. J. Hum. Genet. 32(2), 243-246 (2024).