For immunochemical detection of α-synuclein
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Alternative(s)
29251α-Synuclein Monoclonal Antibody
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α-Synuclein Rabbit Monoclonal Antibody (Clone RM492)

Item No. 42796

Product Insert (PDF)
Technical Information
Synonyms
  • SNCA
  • α-Syn
Immunogen
A peptide corresponding to residues near the C-terminus of human α-synuclein
Clone Designation
RM492
MW
15 kDa
Formulation (Request formulation change)
100 µg of protein A affinity-purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Species Reactivity
(+) Human(+) Mouse(+) Rat
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µl

    $411

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    Product Description

    α-Synuclein is a 140-amino acid intracellular protein encoded by the SNCA gene in humans.1 It is primarily localized to the synaptic terminal of neurons in both the central and peripheral nervous systems where it has a role in regulation of synaptic vesicle docking and neurotransmitter release.2 α-Synuclein is an intrinsically disordered, multi-domain protein composed of a negatively charged C-terminal domain that provides structural flexibility, a central hydrophobic region with a high propensity to aggregate, and a positively charged N-terminal domain containing a repeated consensus sequence KTKEGV.1,3 It exists as a monomer in the cytoplasm, however, mutations, posttranslational modifications, and changes in cellular environmental conditions can induce oligomerization and aggregate formation. Aggregated α-synuclein is found in Lewy bodies that occur in Parkinson’s disease and diffuse Lewy body disease, as well as in glial cells in postmortem brains from patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS). Cayman's α-Synuclein Rabbit Monoclonal Antibody (Clone RM492) can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes α-synuclein at approximately 15 kDa from human, mouse, and rat samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Villar-Piqué, A., da Fonseca, T.L., and Outeiro, T.F. Structure, function and toxicity of alpha-synuclein: The Bermuda triangle in synucleinopathies. J. Neurochem. 139(Suppl 1), 240-255 (2016).

    2. Rocha, E.M., De Miranda, B., and Sanders, L.H. Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease. Neurobiol. Dis. 109(Pt B), 249-257 (2017).

    3. Bendor, J.T., Logan, T.P., and Edwards, R.H. The function of α-synuclein. Neuron 79(6), 1044-1066 (2013).