Progesterone Rabbit Monoclonal Antibody (Clone RM434)

Progesterone is the biosynthetic precursor of all other steroid hormones.^1,2 Progesterone is synthesized from cholesterol by the sequential action of desmolase in the mitochondria, which produces pregnenolone, followed by Δ^4,5-isomerase in the outer mitochondrial membrane and smooth endoplasmic reticulum of steroid-secreting cells.³ The main function of progesterone is to prepare the uterine lining for implantation of a fertilized ovum and to maintain pregnancy. Serum or plasma progesterone levels have been used as an index to monitor ovulation and investigate luteal function. Formulations containing progesterone have been used in support of early pregnancy in infertile women, prevention of endometrial hyperplasia, and the treatment of secondary amenorrhea and abnormal uterine bleeding. Cayman’s Progesterone Rabbit Monoclonal Antibody (Clone RM434) can be used for ELISA.

WARNING This product is not for human or veterinary use.

1.  Hormone action. Biochemistry 2nd ed., 1045-1085 (1988).

2.  Disorders of steroidogenesis guide to steroid profiling and biochemical diagnosis. 1, (2019).

3. Erickson, G.F. The ovary: Basic principles and concepts. A. Physiology. Endocrinology and Metabolism 973-1015 (1995).