For immunochemical detection of cAMP
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Cyclic AMP Rabbit Monoclonal Antibody (Clone RM466)

Item No. 42803

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Adenosine 3',5'-cyclic mononucleotide
  • Adenosine 3',5'-cyclic monophosphate
  • cAMP
Immunogen
cAMP-KLH conjugate
Clone Designation
RM466
Formulation (Request formulation change)
50 µg of protein A-affinity purified antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ELISA
Cross Reactivity
(+) cAMP(-) Adenosine(-) AMP(-) ADP(-) ATP(-) cCMP(-) cGMP(-) cIMP(-) guanosine(-) GMP(-) GDP(-) GTP
Species Reactivity
(Independent) Species
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 µg

    $437

    Add
    Product Description

    Cyclic AMP (cAMP) is a ubiquitous cellular second messenger and critical component of G protein-coupled receptor (GPCR) pathways that use Gαs or Gαi subunits for signaling.1 cAMP is synthesized by membrane-bound adenylate cyclase from ATP after the binding of ligands to Gαs-linked GPCRs. It activates various targets, including PKA, the guanine nucleotide exchange factor EPAC, and cyclic nucleotide-gated ion channels, that have roles in a wide variety of cellular processes from gene transcription to calcium signaling.1,2 cAMP synthesis is prevented by Gαi-linked GPCR activation, which inhibits adenylate cyclase, and its activity can be attenuated by phosphodiesterase-mediated hydrolysis to AMP.1 Therefore, the concentration of cAMP in a cell is a function of the ratio of synthesis from ATP by adenylate cyclase and its rate of breakdown to AMP by phosphodiesterases. Cayman’s Cyclic AMP Rabbit Monoclonal Antibody (Clone RM466) can be used for ELISA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sassone-Corsi, P. The cyclic AMP pathway. Cold Spring Harb. Perspect. Biol. 4(12), a011148 (2012).

    2. Fimia, G.M., and Sassone-Corsi, P. Cyclic AMP signalling. J. Cell Sci. 114(Pt 11), 1971-1972 (2001).