For immunochemical detection of cGMP
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Cyclic GMP Rabbit Monoclonal Antibody (Clone RM467)

Item No. 42804

Product Insert (PDF)
Technical Information
Synonyms
  • cGMP
  • Guanosine 3',5'-cyclic mononucleotide
  • Guanosine 3',5'-cyclic monophosphate
Immunogen
cGMP-KLH conjugate
Clone Designation
RM467
Formulation (Request formulation change)
50 µg of protein A-affinity purified antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ELISA
Cross Reactivity
(+) cGMP(-) Adenosine(-) AMP(-) ADP(-) ATP(-) cAMP(-) cCMP(-) cIMP(-) Guanosine(-) GMP(-) GDP(-) GTP
Species Reactivity
(Independent) Species
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    50 µg

    $437

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    Product Description

    Cyclic GMP (cGMP) is a key intracellular second messenger that transduces cellular signaling events through cGMP-gated (CNG) ion channels, phosphodiesterases (PDEs), and cGMP-dependent protein kinases (cGKs).1,2,3 cGMP is synthesized from GTP by membrane-bound and soluble guanylate cyclase (GC) enzymes, which are activated in response to a variety of hormones, enterotoxins, drugs, and nitric oxide, among other factors. Intracellular accumulation of cGMP induces ion flux, increases or decreases the cAMP response via inhibition or stimulation of cAMP-dependent PDEs, respectively, and activates cGKs. The relative abundance of cGMP within a given cell can serve as a marker for activation by agonists acting through particulate GC at the cell surface or intracellular activation of soluble GC (sGC) by nitric oxide and its rate of breakdown to GMP by PDEs. cGMP signaling is involved in diverse biological processes, including platelet aggregation, blood pressure regulation, skeletal growth, gastrointestinal ion transport, vision, olfaction, thermosensitization, and synaptic plasticity. Cayman’s Cyclic GMP Rabbit Monoclonal Antibody (Clone RM467) can be used for ELISA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hofmann, F. The cGMP system: Components and function. Biol. Chem. 401(4), 447-469 (2020).

    2. Kuhn, M. Molecular physiology of membrane guanylyl cyclase receptors. Physiol. Rev. 96(2), 751-804 (2016).

    3. Schmidt, H.H.H.W., Lohmann, S.M., and Walter, U. The nitric oxide and cGMP signal transduction system: Regulation and mechanism of action. Biochim. Biophys. Acta 1178, 153-175 (1993).