For immunochemical detection of ULK1 (phospho-Ser757)
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ULK1 (Phospho-Ser757) Rabbit Monoclonal Antibody (Clone RM488)

Item No. 42818

Product Insert (PDF)
Technical Information
Synonyms
  • ATG1
  • Autophagy-related 1 Homolog
  • Unc-51-like Autophagy Activating Kinase 1
Immunogen
A phospho-peptide corresponding to ULK1 (phospho-Ser757)
Clone Designation
RM488
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
WB
Cross Reactivity
(+) ULK1 (phospho-Ser757)(-) Unmodified ULK1
Species Reactivity
(+) Human(+) Mouse(+) Rat
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Unc-51-like autophagy activating kinase 1 (ULK1), also known as autophagy-related 1 homolog (ATG1), is a kinase involved in initiating autophagy.1,2 It is composed of an N-terminal kinase domain, a proline serine-rich domain, and two C-terminal microtubule-interacting and transporter (MIT) domains.2 ULK1 forms a complex with ATG12, ATG5, and ATG15L1 to sequester cargo in autophagosomes prior to transport to and fusion with lysosomes.1,3 It is activated when AMP-activated protein kinase (AMPK) phosphorylates Ser317 and Ser777 in response to low nutrient availability and deactivated when mTORC1 phosphorylates Ser757.4,5 ULK1 phosphorylates and deactivates STING in response to STING-induced increases in levels of cyclic dinucleotides.6 Cayman's ULK1 (Phospho-Ser757) Rabbit Monoclonal Antibody (Clone RM488) can be used for Western blot (WB).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Parzych, K.R., and Klionsky, D.J. An overview of autophagy: Morphology, mechanism, and regulation. Antioxid. Redox Signal. 20(3), 460-473 (2014).

    2. Lin, M.G., and Hurley, J.H. Structure and function of the ULK1 complex in autophagy. Curr. Opin. Cell Biol. 39, 61-68 (2016).

    3. Chang, Y.Y., Juhász, G., Goraksha-Hicks, P., et al. Nutrient-dependent regulation of autophagy through the target of rapamycin pathway. Biochem. Soc. Trans. 37, 232-236 (2009).

    4. Kim, J., Kundu, M., Viollet, B., et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13(2), 132-141 (2011).

    5. He, S., Li, Q., Jiang, X., et al. Design of small molecule autophagy modulators: A promising druggable strategy. J. Med. Chem. 61(11), 4656-4687 (2017).

    6. Konno, H., Konno, K., and Barber, G.N. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155(3), 688-698 (2013).