For immunochemical detection of annexin A1
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Annexin A1 Rabbit Monoclonal Antibody (Clone RM424)

Item No. 42828

Product Insert (PDF)
Technical Information
Synonyms
  • p35
  • Annexin I
  • ANXA1
  • Calpactin II
  • Chromobindin-9
  • Lipocortin I
Immunogen
A peptide corresponding to the N-terminus of human Annexin A1
Clone Designation
RM424
Formulation (Request formulation change)
100 µl of protein A-affinity purified recombinant monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) Annexin A2
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Annexin A1 is a member of the annexin superfamily with roles in eicosanoid generation, innate and adaptive immunity, and the resolution of inflammation.1,2,3,4 Under homeostatic conditions, annexin A1 is localized in the cytosol and expressed primarily in innate immune cells, including eosinophils, mast cells, macrophages, neutrophils, and monocytes, but is also expressed in lymphocytes.1,4 Annexin A1 interacts with phospholipase A2 (PLA2) to prevent eicosanoid synthesis and reduce neutrophil recruitment into inflammatory sites.5 It also induces neutrophil apoptosis and promotes efferocytosis. Differential expression of annexin A1 has been associated with cancer progression, metastasis, lymphatic invasion, and chemoresistance.3,2 Cayman’s Annexin A1 Rabbit Monoclonal Antibody (Clone RM424) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kelly, L., McGrath, S., Rodgers, L., et al. Annexin-A1: The culprit or the solution? Immunology 166(1), 2-16 (2022).

    2. Araújo, T.G., Mota, S.T.S., Ferreira, H.S.V., et al. Annexin A1 as a regulator of immune response in cancer. Cells 10(9), 2245 (2021).

    3. Ganesan, T., Sinniah, A., Ibrahim, Z.A., et al. Annexin A1: A bane or a boon in cancer? A systematic review. Molecules 25(16), 3700 (2020).

    4. Bruschi, M., Petretto, A., Vaglio, A., et al. Annexin A1 and autoimmunity: From basic science to clinical applications. Int. J. Mol. Sci. 19(5), 1348 (2018).

    5. Sugimoto, M.A., Vago, J.P., Teixiera, M.M., et al. Annexin A1 and the resolution of inflammation: Modulation of neutrophil recruitment, apoptosis, and clearance. J. Immunol. Res. 2016:8239258, (2016).