For immunochemical detection of INI1
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INI1 Rabbit Monoclonal Antibody (Clone RM468)

Item No. 42834

Product Insert (PDF)
Technical Information
Synonyms
  • BAF47
  • BRG1-associated Factor 47
  • Integrase Interactor 1
  • SMARCB1
  • hSNF5
  • SNF5 Homolog
  • SWI/SNF-related Matrix-associated Actin-dependent Regulator of Chromatin Subfamily B Member 1
Immunogen
Peptide corresponding to the C-terminus of human INI1
Clone Designation
RM468
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) INI1
Species Reactivity
(+) Human(+) Mouse(+) Rat
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Integrase interactor 1 (INI1), also known as SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1), is a subunit in the ATP-dependent chromatin remodeling complex switch/sucrose nonfermentable (SWI/SNF).1,2 It is composed of an N-terminal DNA-binding domain, a transcription factor-binding domain, and a C-terminal nucleosome-binding domain.2 INI1 is ubiquitously expressed and found in the nucleus.1 It ejects nucleosomes from compacted DNA/chromatin, which is required for increasing gene expression.2 A cytosolic fragment of INI1 (183-294) binds to HIV-1 integrase and inhibits HIV-1 replication in T cells.3 Inactivating mutations or deletions of SMARCB1, the gene encoding INI1, are commonly found in cancers.1 Cayman's INI1 Rabbit Monoclonal Antibody (Clone RM468) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. St. Pierre, R., and Kadoch, C. Mammalian SWI/SNF complexes in cancer: Emerging therapeutic opportunities. Curr. Opin. Genet. Dev. 42, 56-67 (2017).

    2. He, S., Wu, Z., Tian, Y., et al. Structure of nucleosome-bound human BAF complex. Science 367(6480), 875-881 (2020).

    3. Yung, E., Sorin, M., Pal, A., et al. Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1. Nat. Med. 7(8), 920-926 (2001).