For immunochemical detection of STAT6
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STAT6 Rabbit Monoclonal Antibody (Clone RM473)

Item No. 42838

Product Insert (PDF)
Technical Information
Synonyms
  • IL-4 STAT
  • Signal Transducer and Activator of Transcription 6
Immunogen
Peptide corresponding to residues near the C-terminus of human STAT6
Clone Designation
RM473
Formulation (Request formulation change)
100 µg of protein A affinity-purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) STAT6
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µl

    $411

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    Product Description

    STAT6 is a transcription factor and member of the STAT protein family with roles in innate and adaptive immunity.1,2 It is composed of N-terminal, coiled-coil, DNA-binding, and linker domains that mediate nuclear translocation and export, as well as Src homology 2 (SH2) and C-terminal transactivation domains that are subject to phosphorylation.2 Phosphorylation of STAT6 at tyrosine 641 (Tyr641) is mediated by JAKs in response to stimulation with cytokines or growth factors and induces STAT6 dimerization and nuclear translocation, leading to STAT6-dependent gene transcription.3,1 STAT6 is necessary for STING-induced immune responses to viral infection in vitro and in vivo.4 The levels of phosphorylated STAT6 are increased in thyroid epithelial cells isolated from patients with Grave's disease.5 Cayman's STAT6 Rabbit Monoclonal Antibody (Clone RM473) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ott, N., Faletti, L., Heeg, M., et al. JAKs and STATs from a clinical perspective: Loss-of-function mutations, gain-of-function mutations, and their multidimensional consequences. J. Clin. Immunol. 43(6), 1326-1359 (2023).

    2. Miklossy, G., Hilliard, T.S., and Turkson, J. Therapeutic modulators of STAT signalling for human diseases. Nat. Rev. Drug Discov. 12(8), 611-629 (2013).

    3. Imada, K., and Leonard, W.J. The Jak-STAT pathway. Mol. Immunol. 37(1-2), 1-11 (2000).

    4. Cioiffier, B., Lepage, E., Briere, J., et al. Chop chemotherapy plus rituximab compared with chop alone in elderly patients with diffuse large-B-cell lymphoma. N. Engl. J. Med. 346, 235-242 (2002).

    5. Jiang, X., Zha, B., Liu, X., et al. STAT6 deficiency ameliorates Graves' disease severity by suppressing thyroid epithelial cell hyperplasia. Cell Death Dis. 7(12), e2506 (2016).