For immunochemical detection of CDX2
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

CDX2 Rabbit Monoclonal Antibody (Clone RM495)

Item No. 42847

Product Insert (PDF)
Technical Information
Synonyms
  • Caudal-type Homeobox Protein 2
  • CDX3
  • Homeobox Protein CDX2
Immunogen
Recombinant human CDX2 protein
Clone Designation
RM495
Formulation (Request formulation change)
100 µl of protein A-affinity purified antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC
Cross Reactivity
(+) CDX2
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    CDX2 is a member of the caudal-related homeobox transcription factor family.1 It is composed of an N-terminal nuclear import sequence, a hexapeptide region, and a homeodomain.2 CDX2 is expressed in intestinal epithelial cells and is required for intestinal tract development and function, such as membrane permeability and local inflammation.1,3 Knockout of Cdx2 is embryonic lethal in mice.3 CDX2 has been used as a diagnostic marker for colon cancer.4 Lack of CDX2 expression is correlated with poor prognosis in patients with Stage II or III colon cancer.5 Cayman's CDX2 Rabbit Monoclonal Antibody (Clone RM495) can be used for immunohistochemistry (IHC).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Coskun, M., Troelsen, J.T., and Nielsen, O.H. The role of CDX2 in intestinal homeostasis and inflammation. Biochim. Biophys. Acta 1812(3), 283-289 (2011).

    2. Trinh, K.Y., Jin, T., and Drucker, D.J. Identification of domains mediating transcriptional activation and cytoplasmic export in the caudal homeobox protein Cdx-3. The Journal of Biological Chemisty 274(9), 6011-6019 (1999).

    3. Chawengsaksophak, K., James, R., Hammond, V.E., et al. Homeosis and intestinal tumours in Cdx2 mutant mice. Nature 386(6620), 84-87 (1997).

    4. Zhang, Y.-J., Chen, J.-W., He, X.-S., et al. SATB2 is a promising biomarker for identifying a colorectal origin for liver metastatic adenocarcinomas. EBioMedicine 28, 62-69 (2018).

    5. Dalerba, P., Sahoo, D., Paik, S., et al. CDX2 as a prognostic biomarker in stage II and stage III colon cancer. N. Engl. J. Med. 374(3), 211-222 (2016).