For immunochemical detection of GCDFP-15
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GCDFP-15 Rabbit Monoclonal Antibody (Clone RM504)

Item No. 42855

Product Insert (PDF)
Technical Information
Synonyms
  • EP-GP
  • Extraparotid Glycoprotein
  • gp17
  • Gross Cystic Disease Fluid Protein 15
  • Prolactin-inducible Protein
  • PIP
  • SABP
  • Secretory Actin-binding Protein
Immunogen
A peptide corresponding to the N-terminus of human GCDFP-15
Clone Designation
RM504
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) GCDFP-15
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Gross cystic disease fluid protein 15 (GCDFP-15) is a secretory glycoprotein whose expression is induced by hormones, including prolactin, growth hormone, and dihydrotestosterone.1,2,3 It is composed of an immunoglobulin fold and has aspartyl protease activity.1,2 GCDFP-15 is expressed in apocrine, eccrine, salivary, and sweat glands, among others.4 It is involved in host defense against bacteria, innate and adaptive immunity, fertilization, and tumorigenesis.1,5 Decreased protein levels of GCDFP-15 are associated with increased tumor size and node-positivity in patients with infiltrating apocrine breast carcinomas.6 Saliva levels of GCDFP-15 are decreased in patients with primary Sjögren’s syndrome.7 Cayman’s GCDFP-15 Rabbit Monoclonal Antibody (Clone RM504) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hassan, M.I., Waheed, A., Yadav, S., et al. Prolactin inducible protein in cancer, fertility and immunoregulation: Structure, function and its clinical implications. Cell. Mol. Life Sci. 66(3), 447-459 (2009).

    2. Sharif, R., Bak-Nielsen, S., Hjortdal, J., et al. Pathogenesis of keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein. Prog. Retin. Eye Res. 67, 150-167 (2018).

    3. Murphy, L.C., Tsuyuki, D., Myal, Y., et al. Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP). Regulation of PIP gene expression in the human breast cancer cell line, T-47D. The Journal of Biological Chemisty 262(31), 15236-15241 (1987).

    4. Viacava, P., Naccarato, A.G., and Bevilacqua, G. Spectrum of GCDFP-15 expression in human fetal and adult normal tissues. Virchows Arch. 432(3), 255-260 (1998).

    5. Ihedioha, O.C., Shiu, R.P.C., Uzonna, J.E., et al. Prolactin-inducible protein: From breast cancer biomarker to immune modulator-novel insights from knockout mice. DNA Cell Biol. 35(10), 537-541 (2016).

    6. Honma, N., Takubo, K., Akiyama, F., et al. Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast. Histopathology 47(2), 195-201 (2005).

    7. Gallo, A., Martini, D., Sernissi, F., et al. Gross cystic disease fluid protein-15(GCDFP-15)/prolactin-inducible protein (PIP) as functional salivary biomarker for primary Sjögren’s syndrome. J. Genet. Syndr. Gene Ther. 4, 10 (2013).