For immunochemical detection of UP2
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UP2 Rabbit Monoclonal Antibody (Clone RM507)

Item No. 42858

Product Insert (PDF)
Technical Information
Synonyms
  • UPII
  • Uroplakin II
  • Uroplakin-2
Immunogen
Peptide corresponding to residues near the C-terminus of human UP2
Clone Designation
RM507
Formulation (Request formulation change)
100 µl of protein A-affinity purified antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) UP2
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

    Add
    Cayman Chemical
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    Product Description

    Uroplakin-2 (UP2) is a member of the uroplakin family.1 It is expressed as a proprotein composed of an N-terminal signal peptide and prodomain, which are cleaved in the endoplasmic reticulum (ER), and a C-terminal domain, which contains the mature peptide sequence, which is composed of a serine- and threonine-rich extracellular domain, a transmembrane domain, and a short cytoplasmic tail.1,2 It is expressed in urothelial umbrella cells and forms protective plaques with UP1a, UP1b, and UP3 in the urinary tract.1 Antibodies targeting UP2 have been used in diagnostic panels for identifying cancers that originate in urothelial tissue.3 Cayman's UP2 Rabbit Monoclonal Antibody (Clone RM507) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matuszewski, M.K., Tupikowski, K., Dołowy, Ł., et al. Uroplakins and their potential applications in urology. Cent. European J. Urol. 69(3), 252-257 (2016).

    2. Lin, J.H., Wu, X.R., Kreibich, G., et al. Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane. The Journal of Biological Chemisty 269(3), 1775-1784 (1994).

    3. Hoang, L.L., Tacha, D., Bremer, R.E., et al. Uroplakin II (UPII), GATA3, and p40 are highly sensitive markers for the differential diagnosis of invasive urothelial carcinoma. Appl. Immunohistochem. Mol. Morphol. 23(10), 711-716 (2015).