For immunochemical detection of LAIR-2
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LAIR-2 (human) Match Antibody Pair (Clones RM479/RM480)

Item No. 42871

Product Insert (PDF)
Technical Information
Synonyms
  • CD306
  • Leukocyte-associated Immunoglobulin-like Receptor 2
Clone Designation
RM479/RM480
Formulation (Request formulation change)
Protein A-affinity purified monoclonal antibodies
Host
Rabbit
Applications
Sandwich ELISA, other sandwich assays
Cross Reactivity
(+) LAIR-2(-) LAIR-1
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Capture Antibody: LAIR-2 (human) Rabbit Monoclonal Antibody (Clone RM479)
    Detection Antibody: LAIR-1/2 (human) Rabbit Monoclonal Antibody - Biotinylated (Clone RM480)

    Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) is a soluble homolog of the membrane-bound inhibitory immune receptor LAIR-1.1 LAIR-2, which is composed of a single immunoglobulin-like domain, binds to collagen and inhibits the LAIR-1-collagen interaction and subsequent activation of immunocytes.1,2 It is produced by human peripheral blood mononuclear cells (PBMCs), monocytic and T cell lines, and activated CD4+ T cells.2,3 LAIR-2 fused to the Fc region of human IgG1 inhibits collagen-induced platelet aggregation, adhesion of platelets to collagen-coated coverslips, and binding of collagen to von Willebrand factor (VWF) and glycoprotein VI (GpVI).4 Elevated levels of LAIR-2 have been found in the urine of pregnant women, the synovial fluid of patients with rheumatoid arthritis, and sera from patients with autoimmune thyroid diseases.2,1 Cayman’s LAIR-2 (human) Matched Antibody Pair (Clones RM479/RM480) contains LAIR-2 (human) Rabbit Monoclonal Antibody (Clone RM479) as a capture antibody and LAIR-1 and LAIR-2 (human) Rabbit Monoclonal Antibody – Biotinylated (Clone RM480) as a detection antibody. This antibody pair can be used for sandwich ELISAs or other sandwich assays for the specific detection of LAIR-2 in human samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Simone, R., Pesce, G., Antola, P., et al. Serum LAIR-2 is increased in autoimmune thyroid diseases. PLoS One 8(5), e63282 (2013).

    2. Lebbink, R.J., van den Berg, M.C.W., de Ruiter, T., et al. The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction. J. Immunol. 180(3), 1662-1669 (2008).

    3. Olde Nordkamp, M.J.M., van Roon, J.A.G., Douwes, M., et al. Enhanced secretion of leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) and soluble LAIR-1 in rheumatoid arthritis: LAIR-2 is a more efficient antagonist of the LAIR-1-collagen inhibitory interaction than is soluble LAIR-1. Arthritis Rheum. 63(12), 3749-3757 (2011).

    4. Lenting, P.J., Westerlaken, G.H.A., Denis, C.V., et al. Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member. PLoS One 5(8), e12174 (2010).