An inhibitor of GSNOR
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Cavosonstat

Item No. 42896

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-chloro-4-(6-hydroxy-2-quinolinyl)-benzoic acid
CAS Number
1371587-51-7
Synonyms
  • N91115
Molecular Formula
C16H10ClNO3
Formula Weight
299.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly Soluble: 0.1-1 mg/mlDMSO: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CC=C(C2=NC3=C(C=C2)C=C(O)C=C3)C(Cl)=C1)O
InChi Code
InChI=1S/C16H10ClNO3/c17-13-8-10(16(20)21)1-4-12(13)15-5-2-9-7-11(19)3-6-14(9)18-15/h1-8,19H,(H,20,21)
InChi Key
BXSZILNGNMDGSL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $109

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    10 mg

    $196

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    25 mg

    $382

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    50 mg

    $600

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    Product Description

    Cavosonstat is an inhibitor of S-nitrosoglutathione reductase (GSNOR; IC50 = 16 nM).1 It decreases disease severity, spinal cord T cell infiltration, demyelination, axonal loss, and body weight loss in a mouse model of experimental autoimmune encephalomyelitis (EAE) when administered at a dose of 5 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Muthukaman, N., Deshmukh, S., Tondlekar, S., et al. Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD. Bioorg. Med. Chem. Lett. 28(23-24), 3766-3773 (2018).

    2. Singh, I., Kim, J., Touhidul Islam, S.M., et al. The role of S-nitrosoglutathione reductase (GSNOR) in T cell-mediated immunopathology of experimental autoimmune encephalomyelitis (EAE). Neuroscience 564, 1-12 (2025).