A fluorogenic substrate for β-alanyl aminopeptidase
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H-β-Ala-AMC (trifluoroacetate salt)

Item No. 42913

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-amino-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-propanamide, 2,2,2-trifluoroacetate salt
CAS Number
201847-54-3
Synonyms
  • H-β-Alanine-AMC
  • 7-N-β-Alanylamino-4-methylcoumarin
Molecular Formula
C13H14N2O3 • CF3COOH
Formula Weight
360.3
Purity
≥98%
Emission
440-460 nm
Excitation
340-360 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
O=C1OC2=C(C(C)=C1)C=CC(NC(CCN)=O)=C2.O=C(C(F)(F)F)O
InChi Code
InChI=1S/C13H14N2O3.C2HF3O2/c1-8-6-13(17)18-11-7-9(2-3-10(8)11)15-12(16)4-5-14;3-2(4,5)1(6)7/h2-3,6-7H,4-5,14H2,1H3,(H,15,16);(H,6,7)
InChi Key
BFXHWJNREYBZJN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    H-β-Ala-AMC is a fluorogenic substrate for P. aeruginosa β-alanyl aminopeptidase.1 Upon enzymatic cleavage by β-alanyl aminopeptidase, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify β-alanyl aminopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively. H-β-Ala-AMC has also been used in the synthesis of acetylspermidine-AMC, a fluorogenic substrate for histone deacetylase 10 (HDAC10).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Váradi, L., Hibbs, D.E., Orenga, S., et al. β-Alanyl aminopeptidase-activated fluorogenic probes for the rapid identification of Pseudomonas aeruginosa in clinical samples. RSC Advances 6(64), (2016).

    2. Herp, D., Ridinger, J., Robaa, D., et al. First fluorescent acetylspermidine deacetylation assay for HDAC10 identifies selective inhibitors with cellular target engagement. Chembiochem 23(14), e202200180 (2022).