An inhibitor of PLD1
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PLD1 Inhibitor

Item No. 42918

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3,5-bis(trifluoromethyl)phenyl]-1H-indole-3-propanamide
CAS Number
1001957-60-3
Synonyms
  • Phospholipase D1 Inhibitor
Molecular Formula
C19H14F6N2O
Formula Weight
400.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
FC(F)(F)C1=CC(C(F)(F)F)=CC(NC(CCC2=CNC3=C2C=CC=C3)=O)=C1
InChi Code
InChI=1S/C19H14F6N2O/c20-18(21,22)12-7-13(19(23,24)25)9-14(8-12)27-17(28)6-5-11-10-26-16-4-2-1-3-15(11)16/h1-4,7-10,26H,5-6H2,(H,27,28)
InChi Key
BHMVDTVKBWVKHG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $422

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    25 mg

    $929

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    Product Description

    PLD1 inhibitor is an inhibitor of phospholipase D1 (PLD1).1 It inhibits PLD activity in PLD1-overexpressing A549 cells (IC50 = 1.97 µM). PLD1 inhibitor reduces the viability of A549 lung cancer and HCT116 colorectal cancer cells (IC50s = 18 and 29 µM, respectively). It also inhibits the proliferation, migration, and invasion of A549 cells and induces apoptosis in the same cells. PLD1 inhibitor (10 mg/kg every other day) reduces tumor growth, induces intratumoral apoptosis, and decreases Ras, CD47, CD24, and programmed cell death 1 ligand 1 (PD-L1) levels in a murine Lewis lung carcinoma model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Song, D., Lim, S.H., Kim, Y., et al. Development and evaluation of indole-based phospholipase D inhibitors for lung cancer immunotherapy. J. Med. Chem. 5170-5189 (2025).