An ionizable cationic glycerolipid
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Lipid TG4C

Item No. 42941

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
hexanedioic acid, 1,1′-[2-[4-(dimethylamino)-1-oxobutoxy]-1,3-propanediyl] 6,6′-bis(1-octylnonyl) ester
CAS Number
3028336-07-1
Molecular Formula
C55H103NO10
Formula Weight
938.4
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
CN(C)CCCC(OC(COC(CCCCC(OC(CCCCCCCC)CCCCCCCC)=O)=O)COC(CCCCC(OC(CCCCCCCC)CCCCCCCC)=O)=O)=O
InChi Code
InChI=1S/C55H103NO10/c1-7-11-15-19-23-27-36-48(37-28-24-20-16-12-8-2)64-53(59)42-33-31-40-51(57)62-46-50(66-55(61)44-35-45-56(5)6)47-63-52(58)41-32-34-43-54(60)65-49(38-29-25-21-17-13-9-3)39-30-26-22-18-14-10-4/h48-50H,7-47H2,1-6H3
InChi Key
CNJVKTXUIDKKIW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Lipid TG4C is an ionizable cationic glycerolipid (pKa = 6.71) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing lipid TG4C and encapsulating mRNA encoding human erythropoietin (EPO) increase serum EPO levels in mice. Nebulized administration of LNPs containing lipid TG4C and encapsulating mRNA encoding human hepatocyte growth factor (HGF) reduces bronchoalveolar lavage fluid (BALF) levels of Il-1β, Il-6, and Tnf-α in a mouse model of pulmonary emphysema induced by porcine pancreatic elastase.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, K., Liu, Y., Miao, H., et al. Nebulized lipid nanoparticles based on degradable ionizable glycerolipid for potent pulmonary mRNA delivery. ACS Nano 19(1), 1128-1139 (2025).