A FAK activator
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ZINC40099027

Item No. 42956

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1-pyrrolidinecarboxamide
CAS Number
1211825-25-0
Synonyms
  • ZN27
Molecular Formula
C23H26F3N3O3
Formula Weight
449.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N1CCCC1C2=CC=C(OC)C=C2)NC3=CC(C(F)(F)F)=CC=C3N4CCOCC4
InChi Code
InChI=1S/C23H26F3N3O3/c1-31-18-7-4-16(5-8-18)20-3-2-10-29(20)22(30)27-19-15-17(23(24,25)26)6-9-21(19)28-11-13-32-14-12-28/h4-9,15,20H,2-3,10-14H2,1H3,(H,27,30)
InChi Key
MOEURIVQRFKTCR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $58

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    5 mg

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    10 mg

    $487

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    25 mg

    $858

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    Cayman Chemical
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    Product Description

    ZINC40099027 is an activator of focal adhesion kinase (FAK).1 It induces FAK autophosphorylation in Caco-2 colon adenocarcinoma cells when used at a concentration of 10 nM. ZINC40099027 (10 nM) increases migration in a wound healing assay using Caco-2 cells. It increases wound closure and decreases ulcer area in a mouse model of acid-induced intestinal ulceration.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, Q., More, S.K., Vomhof-DeKrey, E.E., et al. Small molecule FAK activator promotes human intestinal epithelial monolayer wound closure and mouse ulcer healing. Sci. Rep. 9(1), 14669 (2019).