A Wnt/β-catenin inhibitor and AMPK activator
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YW2065

Item No. 42959

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2-bromophenyl)-5-methyl-N-2-quinolinyl-1H-pyrazole-4-carboxamide
CAS Number
2131223-85-1
Molecular Formula
C20H15BrN4O
Formula Weight
407.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=C(C)N(C2=CC=CC=C2Br)N=C1)NC3=CC=C4C=CC=CC4=N3
InChi Code
InChI=1S/C20H15BrN4O/c1-13-15(12-22-25(13)18-9-5-3-7-16(18)21)20(26)24-19-11-10-14-6-2-4-8-17(14)23-19/h2-12H,1H3,(H,23,24,26)
InChi Key
ATYUYECWVYSPBS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $116

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    10 mg

    $208

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    50 mg

    $462

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    100 mg

    $809

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    Cayman Chemical
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    Product Description

    YW2065 is an inhibitor of Wnt/β-catenin signaling and an activator of AMP-activated protein kinase (AMPK).1 It induces degradation of β-catenin and increases the levels of Axin1 and phosphorylated AMPK and acetyl-CoA carboxylase (ACC), which is a downstream substrate of AMPK, in SW620 colorectal cancer cells when used at a concentration of 3 µM. YW2065 inhibits recombinant human Wnt3a-induced reporter activation in HEK293 cells (IC50 = 2.3 nM) and the growth of SW480 colorectal cancer cells (GI50 = 2.4 nM). In vivo, YW2065 (50 mg/kg) decreases tumor volume and weight in an SW620 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, W., Li, Y., Ai, Y., et al. Pyrazole-4-carboxamide (YW2065): A therapeutic candidate for colorectal cancer via dual activities of Wnt/β-catenin signaling inhibition and AMP-activated protein kinase (AMPK) activation. J. Med. Chem. 62(24), 11151-11164 (2019).