An activator of K2P2.1/TREK-1 and K2P10.1/TREK-2
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ML-402

Item No. 42962

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(4-chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide
CAS Number
298684-44-3
Molecular Formula
C14H14ClNO2S
Formula Weight
295.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
ClC1=CC(C)=C(OCCNC(C2=CC=CS2)=O)C=C1
InChi Code
InChI=1S/C14H14ClNO2S/c1-10-9-11(15)4-5-12(10)18-7-6-16-14(17)13-3-2-8-19-13/h2-5,8-9H,6-7H2,1H3,(H,16,17)
InChi Key
RULQUKFOBAPKKR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $171

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    25 mg

    $332

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    50 mg

    $568

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    Product Description

    ML-402 is an activator of the two-pore domain potassium channels K2P2.1/TREK-1 and K2P10.1/TREK-2.1 It selectively activates K2P2.1/TREK-1 and K2P10.1/TREK-2 expressed in Xenopus oocytes (EC50s = 13.7 and 5.9 µM, respectively) over K2P4.1/TRAAK expressed in Xenopus oocytes at 100 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lolicato, M., Arrigoni, C., Mori, T., et al. K2P2.1(TREK-1): Activator complexes reveal a cryptic selectivity filter binding site. Nature 547(7663), 364-368 (2017).