A derivative of NOTA
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NOTA-bis(tBu ester)

Item No. 42964

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
hexahydro-1H-1,4,7-triazonine-1,4,7-triacetic acid, 1,4-bis(1,1-dimethylethyl) ester
CAS Number
1161415-28-6
Synonyms
  • N(tEB)2
Molecular Formula
C20H37N3O6
Formula Weight
415.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/mlPBS (pH 7.2): Soluble: ≥ 10 mg/ml
SMILES
O=C(OC(C)(C)C)CN(CCN1CC(O)=O)CCN(CC1)CC(OC(C)(C)C)=O
InChi Code
InChI=1S/C20H37N3O6/c1-19(2,3)28-17(26)14-22-9-7-21(13-16(24)25)8-10-23(12-11-22)15-18(27)29-20(4,5)6/h7-15H2,1-6H3,(H,24,25)
InChi Key
UACSRZWSADEYPK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

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    25 mg

    $175

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    50 mg

    $270

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    Cayman Chemical
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    Product Description

    NOTA-bis(tBu ester) is a derivative of the macrocyclic chelator NOTA.1 It has been used in the synthesis of albumin-dimerizing conjugates that prevent peptide proteolysis in vivo and HER2-specific compounds and bombesin receptor 2-specific peptides chelated to radioactive metals for tumor imaging in vivo.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tian, R., Zhu, S., Zeng, Q., et al. An albumin sandwich enhances in vivo circulation and stability of metabolically labile peptides. Bioconjug. Chem. 30(6), 1711-1723 (2019).

    2. Tolmachev, V., Altai, M., Sandström, M., et al. Evaluation of a maleimido derivative of NOTA for site-specific labeling of affibody molecules. Bioconjug. Chem. 22(5), 894-902 (2011).

    3. Varasteh, Z., Velikyan, I., Lindeberg, G., et al. Synthesis and characterization of a high-affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging. Bioconjug. Chem. 24(7), 1144-1153 (2013).