An RGD-containing tetrapeptide
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RGDV (trifluoroacetate salt)

Item No. 42965

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginylglycyl-L-α-aspartyl-L-valine, trifluoroacetate salt
Synonyms
  • Arg-Gly-Asp-Val-OH
Molecular Formula
C17H31N7O7 • XCF3COOH
Formula Weight
445.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
RGDV-OH
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlEthanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
CC(C)[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC(CNC([C@@H](N)CCCNC(N)=N)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C17H31N7O7.C2HF3O2/c1-8(2)13(16(30)31)24-15(29)10(6-12(26)27)23-11(25)7-22-14(28)9(18)4-3-5-21-17(19)20;3-2(4,5)1(6)7/h8-10,13H,3-7,18H2,1-2H3,(H,22,28)(H,23,25)(H,24,29)(H,26,27)(H,30,31)(H4,19,20,21);(H,6,7)/t9-,10-,13-;/m0./s1
InChi Key
ZCTAWGFLPLOTHC-JMHMRROLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    RGDV is a tetrapeptide that contains an arginine-glycine-aspartate (RGD) motif, a sequence that acts as a recognition site for various adhesion proteins.1 It inhibits the binding of fibrinogen to ADP-stimulated platelets and isolated human umbilical vein endothelial cells (HUVECs; IC50s = 18 and 350 µM, respectively).2 RGDV, when conjugated to gemcitabine (Item Nos. 11690 | 9003096), decreases tumor weight and metastasis in an LLC1 murine lung cancer model.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, H.S., Kim, C., and Kang, Y.K. Preferred conformations of RGDX tetrapeptides to inhibit the binding of fibrinogen to platelets. Biopolymers 63(5), 298-313 (2002).

    2. Tranqui, L., Andrieux, A., Hudry-Clergeon, G., et al. Differential structural requirements for fibrinogen binding to platelets and to endothelial cells. J. Cell Biol. 108(6), 2519-2527 (1989).

    3. Zhang, X., Zhang, J., Liu, W., et al. Exploring the action of RGDV-gemcitabine on tumor metastasis, tumor growth and possible action pathway. Sci. Rep. 10(1), 15729 (2020).